The Los Angeles Lakers (3-1) are on the road Wednesday to take on the Cleveland Cavaliers (4-0). Tip-off from Rocket Mortgage FieldHouse is at 7 p.m. ET. Let’s analyze BetMGM Sportsbook’s NBA odds around the Lakers vs. Cavaliers odds and make our expert NBA picks and predictions for the best bets.

Season series: First meeting, Lakers won 2-0 last season

The Lakers started the season with a 3-Game winning streak but are coming off their first loss of the season, a 109-105 defeat to the Phoenix Suns on Monday after leading by as many as 18 points. They covered the 4.5-point spread as road underdogs.

The Cavs have started the season with a 4-game winning streak and have covered the spread in all 4 games. They also played on Monday, beating the New York Knicks 110-104 as 3-point road underdogs.

Lakers at Cavaliers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NBA odds. Lines last updated at 9:59 a.m. ET.

  • Moneyline (ML): Lakers +155 (bet $100 to win $155) | Cavaliers -190  (bet $190 to win $100)
  • Against the spread (ATS): Lakers +4.5 (-105) | Cavaliers -4.5 (-115)
  • Over/Under (O/U): 225.5 (O: -105 | U: -115)

Lakers at Cavaliers key injuries

Lakers

  • Christian Koloko (reconditioning) out
  • Austin Reaves (thigh) probable
  • D’Angelo Russell (back) questionable
  • Jarred Vanderbilt (foot) out
  • Christian Wood (knee) out

Cavaliers

  • Craig Porter (thumb) out
  • Max Strus (ankle) out

For most recent updates: Official NBA injury report.

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Lakers at Cavaliers picks and predictions

Prediction

Cavaliers 119, Lakers 112

Moneyline

The Cavs have simply been rolling to start the season. They have scored over 130 points twice and have allowed opponents to scored under 110 points 3 times. They are No. 3 in scoring and No. 3 in scoring defense.

Four starters are averaging over 17 points per Game.

The Lakers are No. 6 in scoring so far this season, averaging 117.2 points per game. F Anthony Davis leads the NBA at 32.8 PPG. They, like Cleveland, have 4 players averaging more than 17 PPG.

Cleveland’s defense is what gives them the edge, allowing only 106.8 PPG. That gives them the edge, but don’t bet them at -190.

PASS.

Against the spread

The Cavaliers have covered the spread in every game this season. All 4 of their wins have been by at least 6 points and 3 have been by 10 or more.

The Lakers lost their only road game so far this season.

BET CAVALIERS -4.5 (-115).

Over/Under

Both teams are 2-2 O/U. Both meetings last year split 1-1 O/U.

The Cavs have alternated the Over and the Under in all 4 Games this season, and they are coming their lowest total of the young season, 214 in their win over the Knicks.

BET OVER 225.5 (-105).

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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