NFL Week 10 opening lines, odds and best bet | Pickswise

Week 11 of the 2024 NFL regular season is on the immediate horizon and it will begin with Thursday Night Football between the NFC East rival Washington Commanders and Philadelphia Eagles. Sunday’s slate also offers a ton of intriguing, headlined by a pair of divisional contests in Baltimore Ravens vs Pittsburgh Steelers and Seattle Seahawks vs San Francisco 49ers. Perhaps the biggest game of the entire week is a potential AFC Championship preview between the Kansas City Chiefs and Buffalo Bills. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every Game throughout the week – and throughout the entire season. Also make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 11 opening lines and give our best early bet to make.

NFL Week 11 opening lines and odds 

Odds available at DraftKings Sportsbook at time of publishing 

Washington Commanders +3 (-102) vs Philadelphia Eagles -3 (-118) – Thursday Night Football  

Green Bay Packers -6.5 (-110) vs Chicago Bears +6.5 (-110)

Jacksonville Jaguars +12.5 (-105) vs Detroit Lions -12.5 (-115)  

Minnesota Vikings -6.5 (-105) vs Tennessee Titans +6.5 (-115)  

Las Vegas Raiders +6.5 (-104) vs Miami Dolphins -6.5 (-118)   

Los Angeles Rams -5.5 (-105) vs New England Patriots +5.5 (-115) 

Cleveland Browns +2.5 (-105) vs New Orleans Saints -2.5 (-115)  

Indianapolis Colts +3.5 (-115) vs New York Jets -3.5 (-105)

Baltimore Ravens -3.5 (-104) vs Pittsburgh Steelers +3.5 (-118) 

Atlanta Falcons -1.5 (-102) vs Denver Broncos +1.5 (-120)  

Seattle Seahawks +7 (-110) vs San Francisco 49ers -7 (-110)

Kansas City Chiefs +1.5 (-105) vs Buffalo Bills -1.5 (-115) 

Cincinnati Bengals +1.5 (-110) vs Los Angeles Chargers -1.5 (-110) — Sunday Night Football  

Houston Texans -6.5 (-115) vs Dallas Cowboys +6.5 (-105) — Monday Night Football 

Best bet for NFL Week 11: Indianapolis Colts +3.5 over New York Jets (-115)

I cannot envision any scenario in which I would be willing to give more than a field goal with the Jets right now. Heck, I might to even pick them to beat anyone straight up! At 3-6 heading into Week 10, New York was pretty much already in must-win mode – and win is the farthest thing from what it did. Aaron Rodgers and company got humiliated 31-6 by the Arizona Cardinals. Now that the Jets are 3-7, a season that never really got off the ground in the first place is now unequivocally over.

With nothing left to play for aside from a very high draft pick in 2025, the Jets may not put in a max effort the rest of the way – starting with a home contest against the Indianapolis Colts on Sunday. The Colts (4-6) are nothing special, but they have not lost by more than 10 points all season long and they have lost by 10 just once. Four of their setbacks have come by 6 points or fewer, including a trio by 3 or fewer. In a matchup between 2 ancient quarterbacks, neither has a high ceiling and Rodgers has a lower floor than Joe Flacco. Plus, Flacco is playing alongside more motivated teaMMAtes. Give me Indy to cover a current +3.5 spread. 

We’ll have NFL Week 11 picks for every Game!