The Kansas City Chiefs (9-0) meet the Buffalo Bills (8-2) at Highmark Stadium Sunday. Kickoff is set for 4:25 p.m. ET (CBS). Below, we look at Chiefs vs. Bills odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Chiefs cashed in their good karma for a miraculous 16-14 victory over the Denver Broncos Sunday. The Broncos marched down the field and milked the clock to set up a chip-shot, game-winning field goal . . . and the Chiefs blocked it to seal the deal. QB Patrick Mahomes threw for 266 yards and 1 TD. He has not thrown a pick in 2 straight games after throwing at least 1 in every other game this season.

The Bills won their fifth straight Sunday with a 30-20 road win against the Indianapolis Colts. They covered as 4.5-point favorites. QB Josh Allen threw 2 picks, but he was great otherwise. He amassed 280 passing yards and 50 on the ground while reaching the end zone for the first time in 4 games.

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Chiefs at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 1:40 p.m. ET.

  • Moneyline (ML): Chiefs +110 (bet $100 to win $110) | Bills -130 (bet $130 to win $100)
  • Against the spread (ATS): Chiefs +2.5 (-110) | Bills -2.5 (-110)
  • Over/Under (O/U): 45.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: Chiefs 9-0 | Bills 8-2
  • ATS: Chiefs 5-4 | Bills 6-4
  • O/U: Chiefs 4-5 | Bills 6-4

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Chiefs at Bills head-to-head

The Bills lead the all-time series 29-25-1. It has been a back-and-forth series in which neither team has dominated for very long. Buffalo took the last 2 regular-season meetings by a combined 7 points, but K.C. has taken 3 consecutive postseason meetings. The Chiefs won in Buffalo 27-24 last January as TE Travis Kelce caught 5 balls for 75 yards and the only 2 TDs Mahomes threw.

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