We’ve tracked line moves for every Week 6 game since Monday morning at BetMGM Sportsbook to see where the big money has come in and how injuries are shaping the market.

The biggest move of the week has been the Tampa Bay Buccaneers (3-2) going from 2-point underdogs to 3.5-point favorites at the New Orleans Saints (2-3) Sunday. What has changed since Monday morning? Saints QB Derek Carr (oblique) was injured in a 26-13 loss at the Kansas City Chiefs (5-0) on Monday Night Football, and rookie QB Spencer Rattler was announced as the starter for Sunday.

Tampa Bay isn’t the only underdog turned favorite in Week 6. The Tennessee Titans (1-3) have gone from 1-point ‘dogs to laying 2.5 when they host the Indianapolis Colts (2-3). Indianapolis RB Jonathan Taylor (ankle) has been ruled out, and WR Michael Pittman Jr. (back) is questionable.

Other noteworthy shifts in the market have been the Buffalo Bills (3-2) going from 3- to 2.5-point favorites at the New York Jets (2-3) on MNF, as well as the LA Chargers (2-2) going from 2.5- to 3-point favorites when they visit the Denver Broncos (3-2) Sunday.

The biggest move for Week 6 totals since Monday morning has been the Buccaneers–Saints Over/Under going from 45.5 to 42, with the assumption being that New Orleans will score fewer points with Rattler under center.

We’ve seen also seen a 2-point move for the Arizona Cardinals (2-3) and Green Bay Packers (3-2) total, going from 49.5 to 47.5. The Under hit in each team’s most recent matchup, with neither allowing more than 23 points in Week 5.

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Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 9:08 p.m. ET. — All games Sunday and ET unless noted.

Jacksonville Jaguars vs. Chicago Bears, 9:30 a.m. (NFL Network)

Oct 6, 2024; Chicago, Illinois, USA; Chicago Bears quarterback Caleb Williams (18) passes the ball against the Carolina Panthers during the third quarter at Soldier Field. Mandatory Credit: Daniel Bartel-Imagn Images

Chicago Bears quarterback Caleb Williams (18) throws against the Carolina Panthers.

  • Current moneyline: Bears -110 (Jaguars -110) | Opener: Bears -135 (Jaguars +110)
  • Current spread: Bears -1 (-105) | Opener: Bears -2 (-110)
  • Current Over/Under: 44.5 | Opener: 43

Arizona Cardinals at Green Bay Packers, 1 p.m. (FOX)

  • Current moneyline: Packers -250 (Cardinals +https://cdn.thefoxposts.com/vimedia/2024/10/14/2165560eec76d90e6b16911b44c3047a.webp) | Opener: Packers -250 (Cardinals +210)
  • Current spread: Packers -5.5 (-110) | Opener: Packers -5 (-110)
  • Current Over/Under: 47.5 | Opener: 49.5

Indianapolis Colts at Tennessee Titans, 1 p.m. (CBS)

  • Current moneyline: Titans -145 (Colts +120) | Opener: Titans -105 (Colts -115)
  • Current spread: Titans -2.5 (-115) | Opener: Titans +1 (-110)
  • Current Over/Under: 43 | Opener: 42.5

Houston Texans at New England Patriots, 1 p.m. (CBS)

  • Current moneyline: Texans -300 (Patriots +240) | Opener: Texans -300 (Patriots +240)
  • Current spread: Texans -6.5 (-115) | Opener: Texans -7 (-110)
  • Current Over/Under: 37.5 | Opener: 38

Tampa Bay Buccaneers at New Orleans Saints, 1 p.m. (FOX)

Aug 25, 2024; New Orleans, Louisiana, USA; New Orleans Saints quarterback Spencer Rattler (18) during the warmups before the game against the Tennessee Titans at Caesars Superdome. Mandatory Credit: Stephen Lew-USA TODAY Sports

New Orleans Saints quarterback Spencer Rattler (18) warming up against the Tennessee Titans.

  • Current moneyline: Buccaneers -185 (Saints +150) | Opener: Buccaneers +110 (Saints -135)
  • Current spread: Buccaneers -3.5 (-105) | Opener: Buccaneers +2 (-110)
  • Current Over/Under: 42 | Opener: 45.5

Cleveland Browns at Philadelphia Eagles, 1 p.m. (FOX)

  • Current moneyline: Eagles -450 (Browns +340) | Opener: Eagles -450 (Browns +350)
  • Current spread: Eagles -8.5 (-110) | Opener: Eagles -8.5 (-110)
  • Current Over/Under: 42.5 | Opener: 44

Washington Commanders at Baltimore Ravens, 1 p.m. (CBS)

  • Current moneyline: Ravens -300 (Commanders +240) | Opener: Ravens -300 (Commanders +240)
  • Current spread: Ravens -6.5 (-115) | Opener: Ravens -6.5 (-110)
  • Current Over/Under: 52 | Opener: 52.5

LA Chargers at Denver Broncos, 4:05 p.m. (CBS)

  • Current moneyline: Chargers -155 (Broncos +130) | Opener: Chargers -150 (Broncos +125)
  • Current spread: Chargers -3 (-105) | Opener: Chargers -2.5 (-120)
  • Current Over/Under: 35.5 | Opener: 36.5

Pittsburgh Steelers at Las Vegas Raiders, 4:05 p.m. (CBS)

Oct 6, 2024; Pittsburgh, Pennsylvania, USA; Pittsburgh Steelers quarterback Justin Fields (2) scrambles with the ball against the Dallas Cowboys during the first quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images

Pittsburgh Steelers quarterback Justin Fields (2) scrambles against the Dallas Cowboys.

  • Current moneyline: Steelers -165 (Raiders +140) | Opener: Steelers -165 (Raiders +140)
  • Current spread: Steelers -3 (-115) | Opener: Steelers -3 (-110)
  • Current Over/Under: 36.5 | Opener: 37

Detroit Lions at Dallas Cowboys, 4:25 p.m. (FOX)

  • Current moneyline: Lions -165 (Cowboys +140) | Opener: Lions -165 (Cowboys +140)
  • Current spread: Steelers -3 (-115) | Opener: Steelers -3 (-115)
  • Current Over/Under: 52.5 | Opener: 52.5

Atlanta Falcons at Carolina Panthers, 4:25 p.m. (FOX)

  • Current moneyline: Falcons -275 (Panthers +220) | Opener: Falcons -225 (Panthers +185)
  • Current spread: Falcons -6 (-110) | Opener: Falcons -5.5 (-110)
  • Current Over/Under: 47 | Opener: 48.5

Cincinnati Bengals at New York Giants, 8:20 p.m. (NBC)

  • Current moneyline: Bengals -190 (Giants +155) | Opener: Bengals -190 (Giants +155)
  • Current spread: Bengals -3.5 (-110) | Opener: Bengals -3.5 (-110)
  • Current Over/Under: 47 | Opener: 48.5

Monday: Buffalo Bills at New York Jets, 8:15 p.m. (ESPN)

Oct 6, 2024; Houston, Texas, USA; Buffalo Bills quarterback Josh Allen (17) is hit by Houston Texans linebacker Azeez Al-Shaair (0) in the second half at NRG Stadium. Mandatory Credit: Thomas Shea-Imagn Images

Buffalo Bills quarterback Josh Allen (17) is hit while facing the Houston Texans.

  • Current moneyline: Bills -135 (Jets +115) | Opener: Bills -155 (Jets +130)
  • Current spread: Bills -2.5 (-110) | Opener: Bills -3 (-110)
  • Current Over/Under: 41 | Opener: 41.5

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