Lizzo reacts to ‘South Park’ poking fun at her in Ozempic episode: ‘My worst fear has been actualized’

Lizzo has entered the chat.

The “About Damn Time” singer, 36, spoke out after “South Park” targeted her in a new Ozempic episode called “The End of Obesity.”

“Guys, my worst fear has been actualized,” she said in a video posted to TikTok Saturday. “I’ve been referenced in a ‘South Park’ episode. I’m so scared.”

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Lizzo – who has been an advocate for body positivity – then mirrored the episode on her screen to show viewers her reaction in a “blind duet.”

The clip featured sitcom character Sharon Marsh walking in the park with Sheila Broflovski, raving about how the “new drugs” she was prescribed were “pretty amazing.”

Marsh said she previously felt “so ashamed” of herself for not having the “willpower” to work out and eat less to shed pounds.

The fictional character then explained that her doctor wouldn’t prescribe her Ozempic or Mounjaro as her insurance wouldn’t cover it because she didn’t have Type II Diabetes.

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However, the medical professional said there was “a whole new obesity drug” for people who couldn’t “afford” the cost of the Celebrity-loved medication.

“I’ve controlled all my cravings to be thinner with Lizzo,” Marsh said, as Lizzo’s mouth dropped in shock.

The clip then rolled into a commercial for the advertised “once-weekly diet suppressor,” which was raved to have “lowered standards and expectations” about weight.

The ad noted that “case studies” cited that “70 percent of patients on Lizzo no longer care about how much they weigh.”

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They also bashed the “Good As Hell” rapper, claiming the drug allows users to “eat everything” they want and “keep physical activity to a minimum.”

Lizzo’s eyes continued to widen as the commercial continued, “Stop listening to Lizzo if you experience suicidal thoughts. Serious side effects include pancreatitis, hypothermia [and] shitting out your ears.”

“That’s crazy,” she said after stopping the clip. “I just feel like, damn, ‘I’m really that bitch.”’

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Referencing “South Park” creators Trey Parker and Matt Stone, she added, “I really showed the world how to love yourself and not give a f–k to a point where these men in Colorado know who the f–k I am and put it on their cartoon that’s been around for 25 years.”

She continued, “I’m really that bitch and I’ll show y’all how to not give a f–k and I’m going to keep on showing you how to not give a f–k.”

Mimicking the commercial jingle, she signed off, “Oh, oh Lizzooo, bitch.”

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Several fans were also left shocked, as one commented, “THAT WAS BRUTAL.”

“I did NOT expect it to go that way,” another added.

“Took it like a queen,” a third chimed in, referring to the hitmaker’s response.

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While Lizzo has always embraced her body, she’s currently in the middle of a scathing lawsuit filed by a group of ex-dancers alleging that she fat-shamed and sexually harassed them.

In September 2023, the “Truth Hurts” singer claimed via her lawyers that the suit should be dismissed for several reasons.

She also spoke out on social media, referring to the allegations as “false” and saying she’d “never criticize or terminate an employee because of their weight.”