Opening college football betting lines, odds and spreads for Week 13 of the CFB season: Rivalry Week is here

We’re through 12 weeks of the 2023 college Football season, and what a fall it’s been! We have certainly gotten eventful matchups every weekend, with plenty of upsets to keep fans entertained while also having enough chalk prevail to keep the top of the rankings loaded with traditional powerhouses. 

Now it’s time to turn our attention to Week 13. It’s rivalry week! The slate is headlined by the Iron Bowl, “The Game” and other classic rivalries throughout college football taking place over Thanksgiving weekend. The opening lines were released at most sportsbooks on Sunday, so let’s take a look at these openers and give our first impressions. 

NCAAF Week 13 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing.  

• Mississippi -12 (-110) vs Mississippi State – Thursday, November 23
• UTSA +3 (-110) vs Tulane – Friday, November 24
• Missouri -7 (-110) vs Arkansas  – Friday, November 24
• Air Force +6.5 (-110) vs Boise State  – Friday, November 24
• Texas Tech +14.5 (-110) vs Texas – Friday, November 24
• Penn State -20 (-110) vs Michigan State – Saturday, November 25
• Oregon State +14 (-110) vs Oregon – Saturday, November 25
• Ohio State +4 (-110) vs Michigan – Saturday, November 25
• Alabama -14.5 (-110) vs Auburn – Saturday, November 25
• Clemson -7.5 (-110) vs South Carolina – Saturday, November 25
• Kentucky +7 (-110) vs Louisville – Saturday, November 25
• UNC -2 (-110) vs NC State – Saturday, November 25
• Texas A&M +11 (-110) vs LSU – Saturday, November 25
• Virginia Tech -2.5 (-110) vs Virginia – Saturday, November 25
• Kansas -6 (-110) vs Cincinnati – Saturday, November 25
• Arizona -12.5 (-110) vs Arizona State – Saturday, November 25
• Colorado +21.5 (-110) vs Utah – Saturday, November 25
• Washington State +16.5 (-110) vs Washington – Saturday, November 25
• San Jose State +3.5 (-110) vs UNLV – Saturday, November 25
• Iowa State +11.5 (-110) vs Kansas State – Saturday, November 25
• Maryland -2 (-110) vs Rutgers – Saturday, November 25
• BYU +17.5 (-110) vs Oklahoma State – Saturday, November 25
• Wisconsin -1.5 (-110) vs Minnesota – Saturday, November 25
• Florida State -6.5 (-110) vs Florida – Saturday, November 25
• Notre Dame -24.5 (-110) vs Stanford – Saturday, November 25
• Georgia -23 (-110) vs Georgia Tech – Saturday, November 25
• California +10 (-110) vs UCLA – Saturday, November 25

We have college Football picks and NCAAF predictions for all the big Games this season!

NCAAF Week 13 best early bet: Kentucky Wildcats +7 vs Louisville Cardinals (-110)

The Kentucky Wildcats are limping into this rivalry matchup, but don’t be fooled by their last result. The Wildcats are coming off a loss at South Carolina where they turned the ball over multiple times inside the red zone en route to a bitter 17-14 defeat. Devin Leary and company left a ton of points on the board and I think we’re getting a bit of value on this number compared to the lookahead line of +5. The Governor’s Cup series has been dominated by Kentucky historically, with 5 of the last 6 meetings having gone the way of the Wildcats, including the last 3 in Louisville by a combined score of 134 to 69. Furthermore, the Cardinals clinched a spot in the ACC title Game with a thrilling victory over Miami last Saturday so I wouldn’t be surprised if they came out a little flat in a spot where the Wildcats should be fired up.