NFL Week 5 opening lines, odds and best bet | Pickswise

Week 5 of the 2024 NFL regular season is on the immediate horizon, and it’s the first this year in which teams have a bye. The Detroit Lions, Tennessee Titans, Philadelphia Eagles and Los Angeles Chargers are all off. However, there is a lot to like about the lineup. All 3 primetime matchups are intriguing (Tampa Bay Buccaneers vs Atlanta Falcons, Dallas Cowboys vs Pittsburgh Steelers and New Orleans Saints vs Kansas City Chiefs) and the London Series kicks off with the undefeated Minnesota Vikings facing the New York Jets. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 5 opening lines and give our best early bet to make. 

NFL Week 5 opening lines and odds 

Odds available at DraftKings Sportsbook at time of publishing 

Tampa Bay Buccaneers +2.5 (-108) vs Atlanta Falcons -2.5 (-112) – Thursday Night Football  

New York Jets +2.5 (+100) vs Minnesota Vikings -2.5 (-110) – NFL London Games 

Carolina Panthers +4 (-110) vs Chicago Bears -4 (-110)  

Baltimore Ravens N/A vs Cincinnati Bengals N/A

Miami Dolphins -1 (-105) vs New England Patriots +1 (-115)   

Cleveland Browns +3.5 (-110) vs Washington CoMMAnders -3.5 (-110) 

Indianapolis Colts -2.5 (-110) vs Jacksonville Jaguars +2.5 (-110)  

Buffalo Bills N/A vs Houston Texans N/A

Las Vegas Raiders +1.5 (-110) vs Denver Broncos -1.5 (-110) 

Arizona Cardinals +7.5 (-110) vs San Francisco 49ers –7.5 (-110)  

Green Bay Packers -3.5 (-110) vs Los Angeles Rams +3.5 (-110) 

New York Giants +6.5 (-110) vs Seattle Seahawks -6.5 (-110) 

Dallas Cowboys +2 (-110) vs Pittsburgh Steelers -2 (-110) — Sunday Night Football  

New Orleans Saints +5.5 (-112) vs Kansas City Chiefs -5.5 (-108) — Monday Night Football 

Best bet for NFL Week 5: Washington Commanders -3.5 over Cleveland Browns (-110) 

London is calling bettors to the window for Sunday’s opening Game, a 9:30 am ET start time at Tottenham Hotspur Stadium. You probably don’t even need my advice to understand that Washington is the obvious play in this situation. Perhaps more valuable advice is to jump on it right now, because this line is going to move in the favorite’s direction.

Nobody was forecasting this before the season started, but the Commanders are an absolute wagon. Jayden Daniels is setting the league on fire in the early stages of his rookie campaign, a la CJ Stroud of the Houston Texans in 2023. Daniels (897 passing yards, 218 rushing yards, 7 total touchdowns) has his team at 3-1 and riding a 3-game winning streak. At the other end of the spectrum is Deshaun Watson, who appears to be washed up and the recipient of what is arguably the worst contract in all of sports. The Browns are 1-3 and on the fast track to nowhere.

Anything other than a comfortable win or the CoMMAnders would be a big surprise. 

We’ll have NFL Week 5 picks for every game!