NFL Week 13 opening lines, odds and best bet | Pickswise

Week 13 of the 2024 NFL regular season is on the immediate horizon and it’s a feast – quite literally – for Football fans. It begins with a traditional Thanksgiving trio of Games on Thursday, with the Lions, Cowboys and Packers looking to treat their home crowds to victories. There is also a Friday Game on offer, as Kansas City hosts Las Vegas in an AFC West showdown. The week also features 49ers vs Bills on SNF and wraps up with the Browns visiting the Broncos on MNF.  

Make sure you check out our NFL predictions as we add our picks on the side and total for every Game throughout the week – and throughout the entire season. Also make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 13 opening lines and give our best early bet to make.

NFL Week 13 opening lines and odds 

Odds available at DraftKings Sportsbook at time of publishing 

Chicago Bears +10.5 (-110) vs Detroit Lions -10.5 (-110) – Thursday 

New York Giants +4 (-112) vs Dallas Cowboys -4 (-108) – Thursday

Miami Dolphins +3.5 (-110) vs Green Bay Packers -3.5 (-110) – Thursday 

Las Vegas Raiders +13 (-110) vs Kansas City Chiefs -13 (-110)  

Houston Texans -6 (-110) vs Jacksonville Jaguars +6 (-110)   

Arizona Cardinals +4 (-110) vs Minnesota Vikings -4 (-110) 

Seattle Seahawks -1.5 (-110) vs New York Jets +1.5 (-110)  

Los Angeles Chargers -1.5 (-110) vs Atlanta Falcons +1.5 (-110)

Pittsburgh Steelers +2.5 (-105) vs Cincinnati Bengals -2.5 (-115)

Indianapolis Colts -2.5 (-118) vs New England Patriots +2.5 (-102) 

Tennessee Titans +6 (-110) vs Washington Commanders -6 (-110)  

Tampa Bay Buccaneers -6 (-110) vs Carolina Panthers +6 (-110)

Los Angeles Rams OFF (OFF) vs New Orleans Saints OFF (OFF)

Philadelphia Eagles OFF (OFF) vs Baltimore Ravens OFF (OFF) 

San Francisco 49ers +6.5 (-120) vs Buffalo Bills -6.5 (-120) — Sunday Night Football  

Cleveland Browns +5.5 (-110) vs Denver Broncos -5.5 (-110) — Monday Night Football 

Best bet for NFL Week 13: Seattle Seahawks -1.5 over New York Jets (-110)

The Jets are pretty much always outstanding fade candidates, and this week is no exception even though they are coming off a bye. It’s not like this some kind of elite coaching staff that is going to come up with an intricate scheme during its extra time to prepare. Quite the opposite, in fact. Things have only gotten worse since former head coach Robert Saleh was fired much earlier in the season. Aaron Rodgers and company are 3-8 overall and 1-7 in their last 8 games.

 Meanwhile, Seattle has looked like a different team coming out of its bye week. The well-rested Seahawks promptly won 2 in a row, first in San Francisco (which had Brock Purdy, Christian McCaffrey and Nick Bosa playing in that game) and then on Sunday via a 16-6 stomping of Arizona. Seattle is 6-5 and tied atop the NFC West, so it has everything to play for. New York has nothing to play. Give me the ‘Hawks all day long. 

We’ll have NFL Week 13 picks for every game!