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Louisville vs Winthrop Prediction 11-22-24 College Basketball Picks

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Winthrop (4-2) vs. Louisville (2-1)
November 22, 2024 7:00 pm EDT
The Line: Louisville -16.5; Over/Under: 156.5
(Get latest betting odds)

The Winthrop Eagles and the Louisville Cardinals meet Friday in College Basketball action from KFC Yum! Center. Here’s a Louisville vs Winthrop prediction. We will look at this from a betting perspective and determine the best Louisville vs Winthrop pick.

Winthrop Eagles Betting Preview

This year the Eagles have been busy, with six Games in the can already. Winthrop went 3-2 over their first five Games, with wins over Piedmont, Little Rock and William & Mary. The two losses were to Virginia Tech and Georgia Southern.


In the NC Central matchup on Sunday, Winthrop got back into the win column—barely. The Eagles were down 40-39 by halftime but fought back for the 77-75 result. Kelton Talford was the leading scorer with his 22 points and 10 rebounds.

Louisville Cardinals Betting Preview

Over on the Cardinals’ side, they’ve only played three Games so far this year. The opener was a pretty routine blowout win over Morehead State, as Louisville took that one 93-45. Game two was a blowout loss 77-55 versus Tennessee

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The Cardinals took another blowout win over Bellarmine on Tuesday. Louisville jumped out to a 48-27 edge at the break and cruised to the win 100-68. Terrence Edwards led the way on 26 point with four rebounds and three assists.

Why the Louisville Cardinals will win

  • Winthrop has lost each of its last seven games against the Atlantic Coast Conference.
  • The home team has won five of Winthrop’s last six games.
  • Winthrop has lost the first half in each of its last seven Friday night games against non-Conference opponents.

Why the Winthrop Eagles will win

  • Louisville has lost each of its last five games following a home win.
  • The road team has won the first half in each of Winthrop’s last four games.

Louisville vs Winthrop Prediction

I’m likely staying with Louisville. The Cardinals have excelled in favorable matchups so far this year and they’re coming off a blowout win. Louisville hit 54.7 percent from the field with a 37-23 rebounding advantage and just nine turnovers in the win over Bellarmine. They’ve scored a combined 193 points in their two wins so far.

As for Winthrop, they’ve scored quite well this year: 77 or more points in five of their six Games. I doubt the Eagles will see such lofty scoreboard heights Friday if Louisville is playing well, though.

Andrew's Free Pick: Louisville Cardinals -16.5

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