The Arizona Cardinals (1-3) are on the road in Week 5 to take on the San Francisco 49ers (2-2) on Sunday. Kickoff from Levi’s Stadium is at 4:05 p.m. ET (FOX). Below, we look at Cardinals vs. 49ers odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.
The Cardinals have lost 2 straight games after a 41-10 win over the LA Rams in Week 2. They lost 42-14 on Sunday at home to the Washington Commanders, allowing 449 total yards and 216 on the ground. The Cardinals were 3.5-point favorites and the Over (49) hit in the loss.
The 49ers evened their record on Sunday, beating the New England Patriots 30-13, covering the 10.5-point spread as home favorites. The Over (42.5) cashed in.
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Cardinals at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 10:46 a.m. ET.
- Moneyline (ML): Cardinals +300 (bet $100 to win $300) | 49ers -375 (bet $375 to win $100)
- Against the spread (ATS): Cardinals +7.5 (-110) | 49ers -7.5 (-110)
- Over/Under (O/U): 49.5 (O: -110 | U: -110)
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2024 betting stats
- ML: Cardinals 1-3 | 49ers 2-2
- ATS: Cardinals 2-2 | 49ers 2-2
- O/U: Cardinals 3-1 | 49ers 3-1
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Cardinals vs. 49ers head-to-head
The Cardinals and 49ers have played each other 75 times. The Niners lead 36-29 and won the last 4 meetings and 7 of the last 10.
In 8 career starts against San Francisco, Cardinals QB Kyler Murray is 2-6, but has through 10 TD passes and only 3 INTs. He has also rushed for 2 TDs against them.
The 49ers beat Arizona 45-29 in Arizona and 35-16 in Santa Clara last season. 49ers QB Brock Purdy is 4-0 against Arizona with 8 TD passes and no INTs.
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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