English Premier League Soccer Parlay for Saturday, 9/21 | Pickswise

After an exciting week of new-look Champions League action, the English Premier League takes center stage again with a blockbuster slate of action on Saturday. West Ham take on Chelsea in the first Game of the day at 7:30 am ET before 6 matchups kick off at 10:00 am ET. The day then wraps up with Manchester United making the trip to Crystal Palace at 12:30 pm ET. We have picked out our EPL soccer parlay picks for Saturday, which pays at +804 odds with DraftKings Sportsbook. You can also find out our Premier League soccer picks for this weekend’s biggest matchups.

Newcastle ML (+145)

Aston Villa ML (-175)

Manchester United ML (+135)

EPL parlay odds: +804

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Newcastle ML over Fulham (+145), 10:00 am ET, Saturday

Newcastle have won their last 6 Games against Fulham and look likely to extend that run when they face off at Craven Cottage. The Magpies have won 3 of their 4 league Games this season and that has come without playing particularly well. Sandro Tonali and Joelinton are big upgrades on their midfield options from last season and they have already reaped the benefits of fewer injuries than they had in the 2023-24 campaign. They face a Fulham team that has just 1 win despite a relatively straightforward fixture list and look vulnerable against Eddie Howe’s side.

Find out the rest of our EPL soccer predictions

Aston Villa ML over Wolves (-175), 10:00 am ET, Saturday

Aston Villa picked up a big win in their Champions League clash with Young Boys on Tuesday and they can repeat the trick when they face rivals Wolves back in the English Premier League. The Villans have won 3 of their 4 league matches this season and face a Wolves team that are in poor form as of late. Gary O’Neil’s team has lost 3 of their 4 Games in the EPL and have conceded 11 times in that run. The visitors lost 3-2 to Brighton in the EFL Cup in midweek and their struggles look set to continue here. Villa’s forward duo of Ollie Watkins and Jhon Duran is one of the best in the top flight and they can further increase the woes of their rivals.

Manchester United ML over Crystal Palace (+135), 12:30 pm ET, Saturday

Crystal Palace have made a poor start to their 2024-25 campaign, taking just 2 points from 12 available at this early point of the season. The Eagles are missing Michael Olise, who moved to Bayern Munich this summer, and speculation surrounding their star defender Marc Guehi seems to have affected his form. They face a Manchester United team that has bounced back from defeat against Liverpool with a 3-0 win over Southampton and a 7-0 victory against Barnsley in the EFL Cup on Tuesday. The Red Devils will be riding high after those results and they look likely to pick up another win on the road.

Read our full Crystal Palace vs Manchester United prediction