The Toronto Blue Jays (10-9) and San Diego Padres (11-10) open a 3-Game series at Petco Park Friday. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Blue Jays vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Padres won 2-1 last season

The Padres are returning home after 2 straight road series. They went 4-2 in those games, losing their last outing 1-0 to the Milwaukee Brewers Wednesday. San Diego is 5-5 straight up at home and 11-10 on the run line this season.

The Blue Jays had their 4-game winning streak snapped in a 6-4 series-finale loss to the New York Yankees Wednesday. They have won 4 of their last 5 and 6 of their last 9. Toronto is 10-9 on the run line this season.

Blue Jays at Padres projected starters

RHP Yariel Rodriguez vs. RHP Matt Waldron

Rodriguez (0-0, 2.45 ERA) makes his 2nd start. The rookie allowed 1 ER on 4 H and 2 BB with 6 K in 3 2/3 IP in his debut, a 5-3 home win, vs. the Colorado Rockies Saturday.

  • 2024 with Buffalo (AAA): Allowed 1 H and 3 BB with 10 K across 6 1/3 scoreless innings in 2 starts
  • Previously played with the Chunichi Dragons in Japan’s Central League

Waldron (0-1, 3.14 ERA) makes his 4th start. He has a 1.64 WHIP, 3.8 BB/9 and 10.0 K/9 in 14 1/3 innings.

  • Last start: No-decision, 5 IP, 1 ER, 3 H, 4 BB, 4 K in 5-2 road loss to Los Angeles Dodgers Saturday
  • Padres are 0-3 in his starts; they were 3-5 in his 8 appearances last season

Win your fantasy baseball league with BaseballHQ.com. For decades, BHQ has been helping players just like you win! BHQ offers Draft Prep and full-season subscriptions. Sign up today and start winning!

Blue Jays at Padres odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:25 a.m. ET.

  • Moneyline (ML): Blue Jays -102 (bet $102 to win $100) | Padres -116 (bet $116 to win $100)
  • Run line (RL)/Against the spread (ATS): Blue Jays -1.5 (+160) | Padres +1.5 (-194)
  • Over/Under (O/U): 8.5 (O: -104 | U: -118)

Blue Jays at Padres picks and predictions

Prediction

Padres 6, Blue Jays 3

Moneyline

BET PADRES (-116).

San Diego has been playing well as of late, and its offense has been hot. The Padres have tallied 6 or more runs in 3 of their last 4 games, all of which came against either the Brewers or Dodgers. Milwaukee and Los Angeles each sit atop their respective divisions, and the Padres went 4-2 in back-to-back series against them from April 12-17.

While the Blue Jays have won consistently over their last 5, they haven’t scored more than 5 runs in a game since April 6, so keeping up with the efficient Padres offense could be difficult. Toronto is just 3-6 on the road as well.

Back PADRES (-116).

Run line/Against the spread

PASS.

There’s not great value here, as the Padres are too expensive as run-line underdogs and the Blue Jays don’t have playable odds as run-line favorites.

Over/Under

LEAN OVER 8.5 (-104).

The Blue Jays are 9-9 O/U on the season and have gone Over in 2 straight games. They have scored at least 4 runs in back-to-back games and tallied exactly 5 in 3 of their last 5.

San Diego has gone Over in 3 of its last 4 and in 5 of its last 7. It is 11-9-1 O/U on the season. The Padres have tallied at least 6 runs in 5 of their last 7 as well, so their offense has been consistently producing as of late.

Back OVER 8.5 (-104).

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow @nathanbeighle_ on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Additional MLB coverage:
BaseballHQ Fantasy Baseball