The Boston Red Sox (17-13) welcome the San Francisco Giants (14-16) to Fenway Park for the 2nd game of a 3-game series Wednesday. First pitch is set for 7:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Red Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Red Sox lead 1-0

Boston continued its winning ways to open the series, beating the Giants 4-0 Tuesday. It has won 3 straight games, including a 17-0 beatdown of the Chicago Cubs Saturday. The Red Sox are 6-8 at home and 16-14 against the spread (ATS).

The Giants have been fickle over the last week, having traded off winning and losing over their last 6 Games. They are 5-8 on the road. San Fran’s offense has been struggling as of late, scoring 3 or fewer runs in 5 straight Games. San Fran is 13-17 ATS on the season.

Giants at Red Sox projected starters

TBD vs. RHP Kutter Crawford

According to reports, RHP Daulton Jefferies (0-1, 22.50 ERA) is expected to make his 2nd start, but the Giants have yet to confirm it. He allowed 5 earned runs on 9 hits and 0 walks with 1 K in 2 innings in his debut, a 13-4 loss at the San Diego Padres March 31.

  • 2024 stats with Triple-A Sacramento: 1-0, 3.44 ERA (18 1/3 IP, 7 ER), 1.04 WHIP in 2 starts and 2 relief appearances
  • Career road stats: 2-5, 7.34 ERA (30 2/3 IP, 25 ER), 1.63 WHIP in 7 starts and 2 relief appearances

Crawford (1-1, 1.35 ERA) makes his 7th start. He has a 1.11 WHIP, 3.0 BB/9 and 9.2 K/9 in 33 1/3 innings.

  • Last start: Loss, 6 IP, 3 ER, 10 H, 0 BB, 4 K in 7-1 home loss to Cubs Friday
  • Red Sox are 2-4 in his 6 starts
  • 2024 home splits: 0-1, 1.62 ERA, 16 2/3 IP, 3 ER, 14 H, 0 HR, 4 BB, 16 K in 3 starts

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Giants at Red Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:49 a.m. ET.

  • Moneyline (ML): Giants +102 (bet $100 to win $102) | Red Sox -120 (bet $120 to win $100)
  • Run line (RL)/Against the spread: Giants -1.5 (+162) | Red Sox +1.5 (-196)
  • Over/Under (O/U): 8.5 (O: -110 | U: -110)

Giants at Red Sox picks and predictions

Prediction

Red Sox 5, Giants 3

Moneyline

BET RED SOX (-120).

Crawford has been a strong option this season for the Red Sox, who have won 3 straight. Their offense has been incredibly consistent, scoring at least 4 runs in 5 of their last 6 games.

The same cannot be said of San Fran, and that difference in consistency offensively is the key here. The Giants have allowed at least 4 runs in 2 of their last 3 games and have failed to score more than 3 in 5 straight. The Giants are the 4th-worst team on the road at 5-9 as well.

Considering those trends, take RED SOX (-120).

Run line/Against the spread

PASS.

The Red Sox are far too expensive as run-line favorites, while the Giants aren’t worth the risk here as underdogs. Avoid a run-line play for either side.

Over/Under

LEAN UNDER 8.5 (-110).

The Giants have gone Under in 4 straight games and are 1-6 O/U in their last 7. Their offense has struggled, while their pitching has remained strong.

The Red Sox are 3-4-2 O/U in their last 9 games and 13-14-3 O/U on the season. They have allowed 0 runs in 2 of their last 3 games and 3 of their last 6. Take UNDER 8.5 (-110).

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