The San Diego Padres (53-50) visit the Washington Nationals (47-54) on Wednesday. First pitch from Nationals Park is scheduled for 6:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Nationals odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 4-0

The Padres have won 3 Games in a row after taking down the Nationals 4-0 on Tuesday and covering as +103 road underdogs. CF Jackson Merrill had 2 RBIs and RHP Randy Vasquez allowed 0 ER in 6 IP to pick up the win.

Washington had a 3-game winning streak snapped with Tuesday’s loss while failing to cover as a -111 home favorite. The offense was held to just 5 hits while LHP DJ Herz allowed 2 ER in 5 IP to pick up the loss.

Padres at Nationals projected starters

RHP Matt Waldron vs. LHP Mitchell Parker

Waldron (5-9, 3.59 ERA) makes his 21st start. He has a 1.16 WHIP, 2.48 BB/9 and 7.91 K/9 in 112 2/3 IP.

  • Last start: Loss, 6 IP, 1 ER, 6 H, 0 BB, 5 K in 7-0 loss at Cleveland Guardians on Friday
  • Career vs. Nationals: 0-1, 3.38 ERA (10 2/3 IP, 4 ER), 9 H, 3 BB, 10 K in 2 starts

Parker (5-5, 3.90 ERA) makes his 18th start. He has a 1.14 WHIP, 2.05 BB/9 and 7.41 K/9 in 92 1/3 IP.

  • Last start: No-decision, 2/3 IP, 5 ER, 3 H, 2 BB, 2 K in 6-5 win at Milwaukee Brewers on July 13
  • Rookie debuted April 15 and has not yet faced Padres in his career

Padres at Nationals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:24 a.m. ET.

  • Moneyline (ML): Padres -115 (bet $115 to win $100) | Nationals -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+140) | Nationals +1.5 (-165)
  • Over/Under (O/U): 8.5 (O: -120 | U: +100)

Padres at Nationals picks and predictions

Prediction

Padres 4, Nationals 3

Moneyline

BET PADRES (-115).

San Diego has taken down Washington in each of the previous 4 matchups this season. It has held opponents to 1 run or fewer in each of its last 3 games and in 4 of its last 6. Its won each of its last 3 games, all on the road, and faces Parker, who did not make it out of the 1st inning in his last start.

Run line/Against the spread

PASS.

The moneyline has the best value in this matchup.

Over/Under

BET UNDER 8.5 (+100).

The Padres have hit the Under in 7 of their last 10 games including each of their last 4, which have all come on the road. They have allowed 1 run or fewer in each of their last 3 games and have scored 4 runs or fewer in 9 of their last 10. The Nationals have hit the Under in back-to-back games and have scored 3 runs or fewer in 4 of their last 9.

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