The San Diego Padres (61-52) and Pittsburgh Pirates (56-55) meet Tuesday to kick-off a 3-game series. First pitch from PNC Park is set for 6:40 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Padres vs. Pirates odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Pittsburgh won 5-1 last season

San Diego routed the Colorado Rockies 10-2 Sunday while covering as a -225 home favorite. The Padres have won back-to-back Games and went 4-1 on their homestand.

Pittsburgh lost 6-5 to the Arizona Diamondbacks Sunday as a -158 home favorite. The Pirates have lost by only 1 run in each of their last 3 losses and in 4 of their last 5 losses. Pittsburgh is 1-2 during this current homestand.

Padres at Pirates projected starters

RHP Dylan Cease vs. LHP Bailey Falter

Cease (11-8, 3.42 ERA) makes his 24th start. He has a 0.99 WHIP, 2.8 BB/9 and 11.5 K/9 in 136 2/3 IP.

  • Last start: Win, 5 2/3 IP, 1 ER, 3 H, 3 BB, 6 K in an 8-1 win over the Los Angeles Dodgers Wednesday
  • Career vs. Pittsburgh: 1-0, 2.53 ERA (10 2/3 IP, 3 ER), 12 H, 1 BB, 9 K in 2 starts

Falter (5-7, 3.95 ERA) makes his 19th start. He has a 1.19 WHIP, 2.6 BB/9 and 6.0 K/9 in 95 2/3 IP.

  • Last start: Win, 5 1/3 IP, 1 ER, 6 H, 0 BB, 3 K in a 6-2 win at Houston Astros Tuesday
  • Career vs. San Diego: 0-0, 16.20 ERA (1 2/3 IP, 3 ER), 3 H, 0 BB, 3 K in 2 relief appearances

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Padres at Pirates odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:08 p.m. ET.

  • Moneyline (ML): Padres -162 (bet $162 to win $100) | Pirates +136 (bet $100 to win $136)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+104) | Pirates +1.5 (-125)
  • Over/Under (O/U): 8 (O: -110 | U: -110)

Padres at Pirates picks and predictions

Prediction

Padres 5, Pirates 4

Moneyline

PASS.

I lean toward the Padres to cover as -162 favorites, but this bet is too risky as the line is set too heavily, especially since the Pirates are 5-1 in their last 6 vs. San Diego. Bet on the run line and/or total instead.

Run line/Against the spread

BET PIRATES +1.5 (-125).

Pittsburgh has played very well vs. San Diego recently, including 3-0 in the last 3 meetings in Pittsburgh.

The Pirates have also been a very good ATS team this season (63-48) and are 18-7 ATS as a home underdog this season.

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Over/Under

BET OVER 8 (-110).

The Over has hit in 2 of Pittsburgh’s last 3 home games and is 3-1 in Pittsburgh’s last 4 overall. For San Diego, the Over is 4-1 in its last 5 road games and 7-3 in its last 10 games overall.

The Over is also 2-0-1 in the last 3 San Diego-Pittsburgh matchups in Pittsburgh.

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