The San Diego Padres (45-41) and Boston Red Sox (43-38) face off in Game 2 of a 3-game series Saturday. First pitch from Fenway Park is set for 4:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Red Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: San Diego leads 1-0

San Diego routed Boston 9-2 in Friday’s series opener while covering as a +139 road underdog. The Padres scored all 9 of their runs in the 5th inning after being down 1-0 entering the inning. San Diego has won 4 straight.

RHP Nick Pivetta picked up the loss, pitching 4 innings while allowing 5 ER, 7 H and 1 BB with 4 K. The Red Sox have lost back-to-back games.

Padres at Red Sox projected starters

RHP Michael King vs. RHP Tanner Houck

King (5-5, 3.75 ERA) makes his 17th start and 18th appearance. He has a 1.29 WHIP, 3.7 BB/9 and 10.5 K/9 through 93 2/3 innings.

  • Last start: Loss, 6 IP, 5 ER, 9 H, 1 BB, 8 K in a 6-2 loss vs. Milwaukee Sunday
  • Career vs. Boston: 2-4, 5.20 ERA (27 2/3 IP, 16 ER), 28 H, 8 BB, 29 K across 2 starts and 10 relief appearances

Houck (7-5, 2.18 ERA) makes his 17th start. He has a 0.97 WHIP, 1.6 BB/9 and 8.8 K/9 through 103 1/3 innings.

  • Last start: No-decision, 6 2/3 IP, 2 ER, 5 H, 1 BB, 7 K in a 7-6 win over Toronto Monday
  • Leads league with 2.18 ERA
  • First career start vs. San Diego

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Padres at Red Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:40 a.m. ET.

  • Moneyline (ML): Padres +115 (bet $100 to win $115) | Red Sox -135 (bet $135 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres +1.5 (-175) | Red Sox -1.5 (+145)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

Padres at Red Sox picks and predictions

Prediction

Padres 6, Red Sox 4

Moneyline

LEAN PADRES (+115). 

San Diego has won 4-straight and is 2-0 in its last 2 on the road while Boston has dropped back-to-back home games. The Padres are also 8-2 in their last 10 overall.

This is a very slight lean as Boston is 7-3 in its last 10 overall and 6-4 in its last 10 vs. San Diego.

Run line/Against the spread

PASS. 

I like the Padres to cover here as they are 44-42 ATS this season while the Red Sox are only 36-45 ATS on the year, but they are not worth the risk of betting on as +1.5 (-160) underdogs. Bet on the moneyline and/or total instead.

Over/Under

BET OVER 8.5 (-115). 

The Over has hit in each of Boston’s last 4 games and is 7-3 in its last 10 overall, also hitting in 4 consecutive home games for the Red Sox. For San Diego, the Over has hit in each of its last 8 games.

Be aware that the Under is 6-3-1 in the last 10 San Diego-Boston matchups.

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