NFL Week 18 opening lines, spreads and odds | Pickswise

Week 18 of the 2023 NFL season is on the immediate horizon. Yes, just 1 week remains. Division titles will be determined and the playoff lineup will be set following Sunday’s action. It doesn’t get any bigger than this when it comes to regular-season competition. The upcoming week is headlined by a huge showdown for the AFC East title between Buffalo and Miami, while it also includes Texans vs Colts and Rams vs 49ers. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every Game. For now, let’s break down the NFL Week 18 opening lines and give our best early bet to make.

NFL Week 18 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing. 

Buffalo Bills -3 (-110) vs Miami Dolphins +3 (-110) 

Houston Texans +1 (-110) vs Indianapolis Colts -1 (-110)

Philadelphia Eagles -6 (-110) vs New York Giants +6 (-110)

Tampa Bay Buccaneers -5.5 (-115) vs Carolina Panthers +5.5 (-105) 

Pittsburgh Steelers -3.5 (-110) vs Baltimore Ravens +3.5 (-110)

Dallas Cowboys -13.5 (-110) vs Washington Commanders +13.5 (-110) 

Atlanta Falcons +4 (-110) vs New Orleans Saints -4 (-110)

New York Jets +2 (-110) vs New England Patriots -2 (-110)  

Jacksonville Jaguars -3.5 (-110) vs Tennessee Titans +3.5 (-110)

Seattle Seahawks -3.5 (-105) vs Arizona Cardinals +3.5 (-115)

Denver Broncos +2.5 (-105) vs Las Vegas Raiders -2.5 (-115) 

Cleveland Browns +4.5 (-110) vs Cincinnati Bengals -4.5 (-110)

Kansas City Chiefs +1 (-110) vs Los Angeles Chargers -1 (-110)

Los Angeles Rams +3.5 (-110) vs San Francisco 49ers -3.5 (-110) 

Best early bet for NFL Week 18: New Orleans Saints -4 over Atlanta Falcons (-110)

How bad is the NFC South? Well, the Falcons are 7-9 and still just a win and a Buccaneers loss away from winning the division. That is the same scenario for the Saints, who are not much better at 8-8. If Tampa Bay falls at Carolina, Atlanta vs New Orleans is for the NFC South crown. The Saints have home-field advantage for this Sunday afternoon affair and they also have momentum on their side. New Orleans kept its hopes alive by winning – and winning big – at Tampa Bay in Week 17 (23-13). Head coach Dennis Allen’s squad has won 3 of its last 4 Games, losing only on the road to the Rams during this stretch. The Falcons, on the other hand, have been a complete disaster of late with 3 losses in their last 4 outings – including a 9-7 stinker at Carolina. Atlanta is hopeless at the most important position in Football (quarterback), so its season-ending swoon will likely continue in New Orleans. Grab this quick at anything less than Saints -6 before the line moves in the home team’s direction. 

We’ll have NFL Week 18 picks for every game this week