NFL Week 1 opening lines, odds and best bet for the 2024-25 season | Pickswise

Week 1 of the 2024 NFL regular season is on the immediate horizon. Yes, professional Football – real, meaningful Football – is almost back! It should begin with a bang too, as the opening schedule includes Ravens vs Chiefs, Packers vs Eagles, Rams vs Lions, Jets vs 49ers and much more. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also, make sure to check out our NFL best bets page for our top picks. For now, let’s break down the NFL Week 1 opening lines and give our best early bet to make.  

NFL Week 1 opening lines and odds 

Odds available at DraftKings Sportsbook at time of publishing.  

• Baltimore Ravens +3 (-115) vs Kansas City Chiefs -3 (-105) – Thursday Night Football  
• Green Bay Packers +2.5 (-110) vs Philadelphia Eagles -2.5 (-110) – Friday  
• New England Patriots +9 (-110) vs Cincinnati Bengals -9 (-110)  
• Arizona Cardinals +5.5 (-110) vs Buffalo Bills -5.5 (-110)  
• Houston Texans -2 (-110) vs Indianapolis Colts +2 (-110)   
• Jacksonville Jaguars +3.5 (-115) vs Miami Dolphins -3.5 (-105) 
• Minnesota Vikings -1 (-110) vs New York Giants +1 (-110)  
• Tennessee Titans +4 (-110) vs Chicago Bears -4 (-110) 
• Pittsburgh Steelers +3 (-110) vs Atlanta Falcons -3 (-110)  
• Carolina Panthers +4 (-110) vs New Orleans Saints -4 (-110)  
• Denver Broncos +5 (-110) vs Seattle Seahawks -5 (-110) 
• Las Vegas Raiders +3.5 (-110) vs Los Angeles Chargers -3.5 (-110)
• Dallas Cowboys +2.5 (-110) vs Cleveland Browns -2.5 (-110)
• Washington Commanders +3 (-110) vs Tampa Bay Buccaneers -3 (-110) 
• Los Angeles Rams +3.5 (-110) vs Detroit Lions -3.5 (-110) — Sunday Night Football  
• New York Jets +4 (-110) vs San Francisco 49ers -4 (-110) — Monday Night Football 

Best early bet for NFL Week 1: Houston Texans -2 over Indianapolis Colts (-110) 

Expectations are sky-high for the Texans after they won the AFC South with a 10-7 record last season. They are +105 favorites to come out on top of the division again, +850 to triumph in the AFC and +1600 to win the Super Bowl. There is no reason why head coach Demeco Ryans’ team can’t accomplish all of that. Houston hit a home run with C.J. Stroud as the #2 overall pick in 2023, and now the second-year signal-caller has even more weapons to work with thanks to the acquisition of wide receiver Stefon Diggs and running back Joe Mixon. The Texans have plenty of talent on the defensive side of the ball, too.

Indianapolis boasts their own promising young QB, Anthony Richardson, but he has not played since Week 4 last year because of a shoulder injury. As such, Richardson and the Colts may take a few weeks to get into a groove. Finally, I’m too concerned about this Game being in Indy. The Colts went 4-5 at home in 2023 and lost to the visiting Texans 23-19 in Week 18. Give me the visitors to win and cover – likely on their way to an eventual AFC South crown. 

We’ll have NFL Week 1 picks for every game!