The Minnesota Twins (53-40) and San Francisco Giants (45-49) open a 3-game set at Oracle Park Friday. First pitch is scheduled for 10:15 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Twins vs. Giants odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting; Giants won 2-1 last season
The Twins took 2 of 3 Games at the Chicago White Sox Monday through Wednesday. They won 3-2 as -197 favorites in the series finale as the Under (8.5) hit. Twins 3B Brooks Lee and SS Carlos Correa hit back-to-back homers in the 6th inning, and C Ryan Jeffers singled in the go-ahead run in the 7th.
The Giants dropped 2 of 3 at home against the Toronto Blue Jays, wrapping up the series with a 5-3 loss as -123 favorites Thursday with the Over (7.5) cashing. San Francisco is just 1-4 in its last 5 games.
Twins at Giants projected starters
RHP Joe Ryan vs. LHP Kyle Harrison
Ryan (6-5, 3.29 ERA) makes his 19th start. He has a 0.97 WHIP, 1.3 BB/9 and 9.7 K/9 in 109 1/3 IP.
- Last start: Win, 5 2/3 IP, 3 ER, 5 H, 1 BB, 8 K in 9-3 home victory vs. Houston Astros Saturday
- 2024 road stats: 2-2, 2.78 ERA (55 IP, 17 ER), 1.00 WHIP, 9.8 K/9 in 9 starts
- Career vs. Giants: 2-0, 0.82 ERA (11 IP, 1 ER), 1.18 WHIP, 9.8 K/9 in 2 starts, including 1-0 with 1.80 ERA (5 IP, 1 ER) in 1 start last year
Harrison (4-4, 4.24 ERA) makes his 16th start. The rookie has a 1.38 WHIP, 2.9 BB/9 and 7.8 K/9 in 80 2/3 IP.
- Last start: Loss, 3 1/3 IP, 4 ER, 4 H, 4 BB, 2 K in 5-4 setback at Cleveland Guardians Saturday
- 2024 home stats: 1-1, 4.10 ERA (37 1/3 IP, 17 ER), 1.31 WHIP, 8.9 K/9 in 7 starts
- Never faced Twins before
Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.
Twins at Giants odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:25 p.m. ET.
- Moneyline (ML): Twins -150 (bet $150 to win $100) | Giants +125 (bet $100 to win $125)
- Run line (RL)/Against the spread (ATS): Twins -1.5 (+110) | Giants +1.5 (-135)
- Over/Under (O/U): 7.5 (O: -115 | U: -105)
Twins at Giants picks and predictions
Prediction
Twins 6, Giants 3
Moneyline
The Twins (-150) have won 12 of their last 17 Games overall and are 8-3 in their last 11 on the road. However, their run line should also hit and is being offered at plus odds.
PASS. Bet the run line and/or total instead.
Run line/Against the spread
Ten of Minnesota’s last 12 wins have been by 2 or more runs. Ryan’s last 2 starts were multi-run wins for Minnesota, and he has owned the Giants in his career, allowing a total of just 1 run in 11 IP across 2 starts.
Harrison has given up 4 or more runs in 4 of his last 5 starts, and the Giants are coming off back-to-back multi-run losses at home to the Blue Jays, the 7th-worst offense in MLB at 4.05 runs per game. The Twins, on the other hand, score 4.94 per game, the 4th-highest average in the majors.
BET TWINS -1.5 (+110).
Over/Under
The Over is 10-5 when San Francisco is a home underdog and 15-12 when the Twins are road favorites. Minnesota is 7-3 to the Over in its last 10 games, while the Giants are 4-1 O/U in their last 5.
Harrison gave up 4 ER in 3 1/3 IP in his last start Saturday against Cleveland, and he should continue to struggle against an even better offense in the Twins.
BET OVER 7.5 (-115).
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