The Milwaukee Brewers (83-61) and San Francisco Giants (71-74) play the middle contest of a 3-Game series Wednesday. First pitch from Oracle Park is set for 9:45 p.m. ET (FS1). Let’s analyze FanDuel Sportsbook’s lines around the Brewers vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Brewers lead 3-1

The Brewers picked up a 3-2 victory in Tuesday’s series opener as a slight favorite (-110) as the Under (7.5) cashed. After the Giants won the season opener at American Family Field on Aug. 27, the Brewers have won each of the past 3 meetings, all as a favorite, with the Under going 2-0-1.

Milwaukee has won just twice in the past 6 games, but it is an impressive 6-2 in the previous 8 outings on the road. The Under has cashed in 5 in a row for the Brewers.

For the Giants, they’ve come alive for 3 wins in the past 5 games, while going 3-0 in the past 3 outings as an underdog on the run line. However, San Francisco is just 4-8 in the past 12 games, while going 0-3 against Milwaukee in that span. The Under has a 3-2 edge in the past 5 games, and 6-5 edge in the previous 11 contests.

Brewers at Giants projected starters

RHP Colin Rea vs. LHP Blake Snell

Rea (12-4, 3.72 ERA) makes his 25th start and 28th appearance. He has a 1.17 WHIP, 2.3 BB/9 and 7.3 K/9 in 150 IP.

  • Last start: No-decision, 4 IP, 2 ER, 4 H, 2 BB, 4 K in 3-2 home loss in 10 innings vs. St. Louis Cardinals
  • 2024 road splits: 5-1, 3.50 ERA, 69 1/3 IP, 27 ER, 9 HR, 1.34 WHIP, .265 opponents’ batting average (OBA), 21 BB, 53 K in 11 starts (13 appearances)
  • Career vs. Giants: 1-2, 5.29 ERA, 17 IP, 10 ER, 4 HR, 0.94 WHIP, 6.9 K/9 in 3 starts

Snell (2-3, 3.62 ERA) makes his 18th start. He has a 1.11 WHIP, 4.0 BB/9 and 12.0 K/9 in 87 IP.

  • Last start: No-decision, 1 IP, 2 R (1 ER), 2 H, 2 BB, 2 K in 3-2 home win vs. Arizona Diamondbacks last Thursday (42 pitches)
  • 2024 home splits: 0-2, 2.96 ERA, 48 2/3 IP, 16 ER, 2 HR, 1.09 WHIP, .190 OBA, 19 BB, 69 K in 10 starts
  • Career vs. Brewers: 0-2, 8.00 ERA, 9 IP, 8 ER, 3 HR, 1.44 WHIP, 14.0 K/9 in 2 starts

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Brewers at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:32 a.m. ET.

  • Moneyline (ML): Brewers +120 (bet $100 to win $120) | Giants -142 (bet $142 to win $100)
  • Run line (RL)/Against the spread (ATS): Brewers +1.5 (-166) | Giants -1.5 (+138)
  • Over/Under (O/U): 7 (O: -108 | U: -112)

Brewers at Giants picks and predictions

Prediction

Brewers 4, Giants 3

Moneyline

The BREWERS (+120) are a solid play on the road behind Rea. Milwaukee is closing in on a NL Central title, while the Giants (-142) are all but eliminated. Milwaukee is a strong value on the road.

In Snell’s last start, he labored through a 42-pitch 1st inning, and he didn’t come back out for the 2nd inning. He appears to have checked out on the season, and the Giants in particular, and Rea is a much less risky play.

Run line/Against the spread

If you just can’t play the BREWERS +1.5 (-166) straight up for some reason, and you need a little insurance, this isn’t priced out of control.

As an underdog, Milwaukee is 6-1 on the run line, and all 6 covers have been outright victories, too.

The Giants -1.5 (+138) are struggling, failing to cash on the run line in the past 3 tries as a favorite, with 2 losses outright.

Over/Under

AVOID.

I see the Total (7) landing right on the number, and it’s a good idea to stay away.

The Over-Under is 6-6-2 in the past 14 games for the Giants, so there is nothing to glean there. If there was a lean, it would be Under, which has cashed in 5 in a row for the Brewers. But, the best plan is to stay away.

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