Week 7 in the NFL concludes with the LA Chargers (3-2) on the road taking on the Arizona Cardinals (2-4) in 1 of the 2 Monday night prime-time Games. Kickoff from State Farm Stadium is at 9 p.m. ET (ESPN+). Let’s analyze BetMGM Sportsbook’s NFL odds around the Chargers vs. Cardinals odds, and make our expert NFL picks and predictions.

The Chargers snapped a 2-game losing streak last week, coming out of their bye week to defeat the Denver Broncos 23-16 as 3-point favorites, holding on after going into the 4th quarter with a 23-0 lead. The Over (37) cashed in.

The Cardinals have lost 3 of their last 4 games and are coming off a blowout 34-13 road loss to the Green Bay Packers, failing to cover the 5.5-point spread as underdogs. They turned the ball over 3 times and allowed QB  Jordan Love to throw 4 TD passes in the game.

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Chargers at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Sunday at 6:12 p.m. ET.

  • Moneyline (ML): Chargers -120 (bet $120 to win $100) | Cardinals +100 (bet $100 to win $100)
  • Against the spread (ATS): Chargers -2 (-110) | Cardinals +2 (-110)
  • Over/Under (O/U): 44 (O: -110 | U: -110)

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Chargers at Cardinals key injuries

Chargers

  • OLB Joey Bosa (hip) doubtful
  • WR DJ Chark Jr. (groin) questionable
  • WR Derius Davis (hamstring) questionable
  • WR Simi Fehoko (shoulder/groin) questionable
  • CB Kristian Fulton (hamstring) questionable
  • TE Hayden Hurst (groin) doubtful
  • WR Quentin Johnston (ankle) dountful
  • CB Deane Leonard (hamstring) out
  • WR Ladd McConkey (hip) questionable
  • CB Ja’Sir Taylor (fibula) questionable

Cardinals

  • RB Trey Benson (illness) questionable
  • Christian Jones (ankle) questionable
  • DL Roy Lopez (ankle) questionable
  • CB Sean Murphy-Bunting (neck) questionable
  • LB Owen Pappoe (hip) out
  • DL Darius Robinson (calf) out
  • LB Kyzir White (knee) questionable
  • CB Garrett Williams (groin) questionable

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Chargers at Cardinals picks and predictions

Prediction

Chargers 20, Cardinals 16

Moneyline

The Chargers do 2 things well that will be challenging for Arizona. They run the ball well, averaging 127.8 rushing yards per game, and they play great defense, having allowed the fewest points in the league (only 13.2 per game).

Arizona has allowed an average of 184.8 rushing yards in its last 4 games and have been held to 14 or fewer points in 3 of its last 4 games.

Over the last 2 seasons, the Cardinals have been blown out 3 times, including last week. In the previous 2 games following the losses, they won as underdogs.

But the Chargers are a bad matchup, especially as 2 of Arizona’s starting defensive linemen are out for the season, making it less likely they can slow the Chargers’ rushing attack.

The Chargers should win this game and the -110 odds are not a bad bet, but you get a little better value with the spread. PASS.

Against the spread

The Chargers are only favored by 2 points, so there isn’t a big difference between an outright win and a cover. They are 3-0 ATS when they have been favored and 0-2 ATS as underdogs.

In all 4 of the Cardinals’ losses this season, they have lost by more than 2 points.

BET CHARGERS -2 (-110).

Over/Under

The Chargers have not had a single game this season reach 40 total points. Their season-high in scoring is 26 points and they average 18.2 per game.

The Cardinals have not scored more than 14 points in 3 of their last 4 games, but they are averaging 22.2 points per game.

BET UNDER 44 (-110). 

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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