The Houston Astros (7-19) and Colorado Rockies (7-19) open a 2-Game interleague series at Estadio Alfredo Harp Helu in Mexico City. First pitch is scheduled for 6:05 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Astros vs. Rockies odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Astros won 3-1 in 2023

The Astros have gotten off to a brutal start, winning just 7 times in the first 26 Games. Houston has dropped 5 in a row and 8 of the past 9 outings. The Under has cashed in 5 straight while going 8-0-1 in the past 9 contests since April 15.

The Rockies picked up a 10-9 win against the San Diego Padres in the series finale Thursday, splitting a 4-game set with the division rivals. The Under is 8-4 in the past 12 games for Colorado.

The books are expecting fireworks, as the venue in Mexico City sits at 7,349 feet above sea level, which is more than 2,000 feet higher than Coors Field in Denver.

Astros vs. Rockies projected starters

RHP Ronel Blanco vs. RHP Cal Quantrill

Blanco (2-0, 1.33 ERA) makes his 5th start of the season. He has a 0.85 WHIP, 4.0 BB/9 and 7.3 K/9 in 27 innings.

  • Last start: No-decision, 6 IP, 2 ER, 5 H (1 HR), 3 BB, 6 K in 5-4 road loss in 10 innings vs. Washington Nationals April 20
  • 2024 road splits: (1-0, 1.50 ERA) with a 1.08 WHIP, 7 BB, 10 K and .146 opponents’ batting average in 2 starts across 12 IP

Quantrill (0-2, 4.33 ERA) makes his 6th start. He has a 1.48 WHIP, 4.0 BB/9 and 5.0 K/9 in 27 innings.

  • Last start: No-decision, 6 IP, 0 ER, 3 H, 5 BB, 4 K in 2-1 home win in 10 innings vs. Seattle Mariners Sunday
  • Career vs. Astros: (1-1, 2.75 ERA) with a 1.32 WHIP, 8 BB, 14 K in 3 starts and 2 relief appearances

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Astros vs. Rockies odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:20 a.m. ET.

  • Moneyline (ML): Astros -225 (bet $225 to win $100) | Rockies +180 (bet $100 to win $180)
  • Run line (RL)/Against the spread (ATS): Astros -2.5 (-120) | Rockies +2.5 (+100)
  • Over/Under (O/U): 16 (O: -105 | U: -115)

Astros vs. Rockies picks and predictions

Prediction

Astros 8, Rockies 6

Moneyline

The Astros (-225) will cost you more than 2 times your potential return, and that’s way too much risk for not enough reward, especially in a venue the players aren’t terribly familiar with.

The Rockies (+180) enter with an identical record as the more heralded Astros, and it is tempting to play the larger underdog.

PASS.

Run line/Against the spread

The ROCKIES +2.5 (+100) at even-money catching the runs is the best bet here. Both of these teams should hit early and often at high elevation, and no lead is expected to be safe. This game should be like Coors Field on steroids, so buckle up and expect a rough ride until the end.

Over/Under

UNDER 16 (-115) is the lean, but go lightly with a half-unit play at most.

This game is being played at high elevation, but a total of 16 is quite a high number. It will be interesting to see how the teams acclimate, as even the Rockies could have trouble moving up 2,000 feet in elevation.

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