The San Francisco 49ers (1-0) and the Minnesota Vikings (1-0) meet in  Week 2 at U.S. Bank Stadium in Minneapolis. Kickoff is scheduled for 1 p.m. ET (CBS). Below, we look at 49ers vs. Vikings odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The 49ers were without RB Christian McCaffrey for Week 1 due to Achilles’ and calf injuries, but RB Jordan Mason stepped in for his 1st NFL start, and his 1st NFL 100-yard Game. Mason ended up with 147 rushing yards and a score in a 32-19 victory over the New York Jets, which was a Scorigami, by the way.

There are reports McCaffrey might sit again in Week 2 due to the artificial turf at U.S. Bank Stadium, so that’s something to watch during the week.

The Vikings paddled the hapless New York Giants 28-6 on the road Sunday in their opener, as QB Sam Darnold tossed 2 TDs, including 1 to superstar WR Justin Jefferson. Unlike the 49ers, the Vikings cashed low on the total in Week 1. Now, Darnold makes his home debut for the Vikings against his 2023 team.

49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Tuesday at 6:11 a.m. ET.

  • Moneyline (ML): 49ers -275 (bet $275 to win $100) | Vikings +220 (bet $100 to win $220)
  • Against the spread (ATS): 49ers -6 (-110) | Vikings +6 (-110)
  • Over/Under (O/U): 45.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: 49ers 1-0 | Vikings 1-0
  • ATS: 49ers 1-0 | Vikings 1-0
  • O/U: 49ers 1-0 | Vikings 0-1

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49ers vs. Vikings head-to-head

This will be the 10th meeting since 2006. Minnesota holds a 5-4 edge in the series during the span. The home side has won 7 straight meetings, with the home team also 6-0 ATS in the previous 6 in this series.

These teams met last season in the Twin Cities, with Minnesota winning 22-17 as a 6.5-point underdog as the Under (44) cashed on Oct. 23, 2023. The Under is 5-1 in the past 6 meetings, and 7-2 in the previous 9 in the series, including the past 3 battles in the Twin Cities.

The teams have played 50 times (6 in the postseason) with the 49ers ahead 25-24-1.

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