The Chicago White Sox (31-109) and Baltimore Orioles (81-59) wrap up a 3-game set Wednesday. First pitch from Oriole Park at Camden Yards is scheduled for 6:35 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Orioles odds and make our expert MLB picks and predictions for the best bets.

Season series: Orioles lead 6-0

The White Sox have lost 12 Games in a row after falling 9-0 against the Orioles Tueday as +274 road underdogs. Chicago was held scoreless for the 16th time this year. The White Sox are 11 losses away from tying the 1962 New York Mets for most losses in a season since 1900.

The Orioles have won 3 games in a row after Tuesday’s victory as -310 home favorites. RF Anthony Santander and LF Colton Cowser each drove in 2 runs while LHP Cade Povich pitched 7 1/3 shutout innings to pick up the win.

White Sox at Orioles projected starters

RHP Jonathan Cannon vs. RHP Albert Suarez

Cannon (2-9, 4.70 ERA) makes his 17th start. He has a 1.41 WHIP, 3.0 BB/9 and 6.2 K/9 through 95 2/3 innings.

  • Last start: Loss, 5 IP, 4 ER, 5 H, 4 BB, 3 K in 5-1 home defeat against Mets Friday
  • Has never faced Orioles

Suarez (7-4, 3.14 ERA) makes his 20th start. He has a 1.27 WHIP, 2.9 BB/9 and 7.0 K/9 through 109 innings.

  • Last start: Win, 7 IP, 2 ER, 8 H, 0 BB, 4 K in 5-3 win at Colorado Rockies Friday
  • Career vs. White Sox: 0-0, 3.00 ERA (6 IP, 2 ER), 5 H, 2 BB, 6 K in 1 start, a 5-3 road win May 25

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

White Sox at Orioles odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:35 a.m. ET.

  • Moneyline (ML): White Sox +275 (bet $100 to win $275) | Orioles -350 (bet $350 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +2.5 (-115) | Orioles -2.5 (-105)
  • Over/Under (O/U): 8.5 (O: -105 | U: -115)

White Sox at Orioles picks and predictions

Prediction

Orioles 5, White Sox 1

Moneyline

PASS.

There is no value on the Orioles (-350) to take down the White Sox, who are on pace to win just 36 Games.

Run line/Against the spread

BET ORIOLES -2.5 (-105).

The White Sox have lost back-to-back games by 9 or more runs, while 5 of their last 10 losses have come by 3 or more. They have been shut out in 2 of their last 3 games and scored 3 runs or fewer in each of their last 9. The Orioles have won 3 games in a row by 5 or more runs while scoring 5 or more in each of their last 5.

Over/Under

BET UNDER 8.5 (-115).

The White Sox have scored 1 run or fewer in 5 of their last 8 games and are 3-6-1 O/U in their last 10. The Orioles have limited opponents to 3 or fewer runs in 4 of their last 5 games.

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