The Chicago Cubs (57-60) and Chicago White Sox (28-89) begin a 2-game series Friday. First pitch from Guaranteed Rate Field is set for 8:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Cubs vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Cubs lead 2-0 with a pair of 7-6 wins June 4-5

The Cubs finished their homestand 5-2 with a 8-2 victory over the Minnesota Twins on Wednesday. They outscored opponents 36-22 in the 7 Games at Wrigley. The Cubs are 25-33 on the road and 55-62 against the spread (ATS).

The White Sox limp home to face their crosstown rivals after snapping a 21-Game losing streak on Tuesday, before losing 3-2 on Wednesday to the Oakland Athletics and firing manager Pedro Grifol. The White Sox were outscored 38-19 in losing 5 of 6 on the road trip. The Southsiders are 17-40 at home and 50-66 ATS.

Cubs at White Sox projected starters

RHP Jameson Taillon vs. LHP Garrett Crochet

Taillon (7-6, 3.25 ERA) makes his 20th start. He has a 1.16 WHIP, 1.8 BB/9 and 7.0 K/9 in 110 2/3 IP.

  • Last start: No-decision, 6 IP, 1 ER, 6 H, 0 BB, 4 K in 5-4 loss against the St. Louis Cardinals Saturday
  • 2024 road splits: 2-3, 4.06 ERA (51 IP, 29 R (23 ER), 1.20 WHIP, 6.0 K/9 in 9 starts
  • Last start vs White Sox: No-decision, 5 IP, 5 ER, 10 H, 1 BB, 6 K in 7-6 home win June 5
  • Career vs. White Sox: 0-0, 3.58 (27 2/3 IP, 11 ER), 1.36 WHIP, 8.6 K/9 in 5 starts

Crochet (6-8, 3.19 ERA) makes his 24th start. He has a 1.01 WHIP, 2.3 BB/9 and 12.3 K/9 in 118 1/3 IP.

  • Last start: No-decision, 4 IP, 1 ER, 1 H, 4 BB, 2 K in 6-2 loss at Twins Saturday
  • 2024 home splits: 4-5, 2.60 ERA (69 1/3 IP, 23 R (20 ER), 0.95 WHIP, 13.4 K/9 in 13 starts
  • Has never started against the Cubs

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Cubs at White Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:53 p.m. ET.

  • Moneyline (ML): Cubs -148 (bet $148 to win $100) | White Sox +126 (bet $100 to win $126)
  • Run line (RL)/Against the spread: Cubs -1.5 (+108) | White Sox +1.5 (-130)
  • Over/Under (O/U): 8 (O: -108 | U: -112)

Cubs at White Sox picks and predictions

Prediction

Cubs 3, White Sox 2

Moneyline

PASS.

I want to love the Cubs in this game, but they are facing the best White Sox  pitcher this season. Crochet has been lights out, but has been on an innings limit. The Cubs will likely win this game against the White Sox bullpen.

If it was any other pitcher for the White Sox, I’d be all about the Cubs. Instead I’ll just avoid and look to the total.

Run line/Against the spread

PASS.

For the same reasons I don’t like the moneyline, I’ll avoid the run line as well. I do not see any edge and the odds don’t even make it tempting.

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Over/Under

BET UNDER 8 (-112).

I’m all in on the Under in this Game because of the pitching matchup. The Under has hit in 2 of Taillon’s last 3 starts, and Crochet is 1-2-2 against the Over in his last 5.

Crochet has not allowed more than 3 ER in any start since April 24. Taillon has allowed more than 3 ER just once in his last 10 starts.

All signs point to this game being a pitching duel that’ll likely come down to the bullpens late.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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