The Buffalo Bills (5-2) and Seattle Seahawks (4-3) meet in Week 8 Sunday. Kickoff from Lumen Field is set for 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Seahawks odds, and make our expert NFL picks and predictions..

The Bills dominated the visiting Tennessee Titans 34-10 Oct. 20, covering as 10-point favorites as the Over (41) hit. QB Josh Allen threw for 323 yards — his first 300-yard game of the season — with 2 TDs, including one to new target WR Amari Cooper. Buffalo’s run game contributed as well, with RBs James Cook and Ray Davis each scoring a rushing TD. The win showcased a balanced attack, helping the Bills secure a comfortable victory at home.

The Seahawks snapped their 3-Game skid with a 34-14 victory as 3-point underdogs at the Atlanta Falcons Oct. 20 while the Under (51.5) hit. RB Kenneth Walker III scored 2 total TDs (1 receiving, 1 rushing), and WR DK Metcalf added 99 receiving yards and a TD. Seattle’s defense played a key role, forcing 3 turnovers from the Falcons, helping secure the win and getting the Seahawks back on track.

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Bills at Seahawks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 1:32 a.m. ET.

  • Moneyline (ML): Bills -160 (bet $160 to win $100) | Seahawks +135 (bet $100 to win $135)
  • Against the spread (ATS): Bills -3 (-110) | Seahawks +3 (-110)
  • Over/Under (O/U): 45.5 (O: -110 | U: -110)

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Bills at Seahawks key injuries

Bills

  • LB Terrel Bernard (ankle/pectoral/personal) out
  • DL DeWayne Carter (wrist) out
  • RB Darrynton Evans (hamstring) doubtful
  • WR Curtis Samuel (pec) out

Seahawks

  • CB Tre Brown (ankle) questionable
  • OL George Fant (knee) questionable
  • OL Abraham Lucas (knee) out
  • WR DK Metcalf (calf) doubtful
  • DL Mike Morris (ankle) questionable
  • CB Nehemiah Pritchett (ankle) questionable
  • DL Cameron Young (knee) doubtful

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Bills at Seahawks picks and predictions

Prediction

Bills 26, Titans 13

Moneyline

PASS.

The Bills (-160) will get it done in Seattle Sunday. I’ve got enough confidence that they will cover the line, as well, which is why I’ll take my bet to the spread.

Against the spread

BET BILLS -3 (-110).

The Bills are 22-13 on the road over the last 5 seasons and have started this year 2-2 away from home. They excel against NFC teams, boasting a 19-5 record in the same period. In contrast, the Seahawks are just 2-2 at home this season and have a concerning -38 point differential overall. Buffalo’s offense should take advantage of Seattle’s vulnerabilities, leveraging Cooper’s addition along with Allen and Cook on the ground.

The Seahawks have a capable offense, but face a Bills defense that ranks 8th in scoring and 5th against the pass. With Metcalf dealing with an MCL strain and listed as week-to-week, the Bills have a great chance to create distance in the AFC East with a road victory in Seattle.

Over/Under

BET UNDER 45.5 (-110).

The last 4 encounters between the Bills and Seahawks have all gone over the total, and both teams are currently riding hot streaks.

The Bills have exceeded the total in their last 2 Games, while the Seahawks have done so in 5 of their 7 matchups this season. Buffalo is averaging over 28 points in its last 2 victories, while Seattle has scored more than 26 points in its previous 4 outings. With both offenses clicking, Sunday’s showdown in Seattle promises to be a high-scoring affair.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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