The Buffalo Bills (7-2) visit the Indianapolis Colts (4-5) on Sunday in Week 10. Kickoff at Lucas Oil Stadium is scheduled for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Colts odds, and make our expert NFL picks and predictions.
QB Josh Allen has led the Bills to a 4-game win streak. Buffalo has scored at least 30 points in 3 straight games, including a key 30-27 victory over the Miami Dolphins to expand their AFC East lead.
Following their 21-13 loss to the Minnesota Vikings on Thursday Night Football, the Colts face their third team in a row with a winning record and look to prevent their losing streak from reaching 3. Indianapolis will stick with Joe Flacco under center over 2023 first-round pick Anthony Richardson to attempt to keep pace and earn a trip to the postseason.
Both clubs will have to go at it without at least 1 top pass-catching weapon, though. How will this impact betting?
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Bills at Colts odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated at 9:49 a.m. ET.
- Moneyline (ML): Bills -210 (bet $210 to win $100) | Colts +170 (bet $100 to win $170)
- Against the spread (ATS): Bills -4 (-110) | Colts +4 (-110)
- Over/Under (O/U): 46.5 (O: -110 | U: -110)
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Bills at Colts key injuries
Bills nickname
- WR Keon Coleman (wrist) out
- WR Amari Cooper (wrist) questionable
Colts nickname
- WR Michael Pittman (back, finger) out
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Bills at Colts picks and predictions
Prediction
Bills 30, Colts 27
Moneyline
The Bills’ ML juice on the road isn’t too costly, but it’s still unfavorable enough not to get excited about.
Flacco being under center justifies a contrarian sprinkle bet on the Colts. However, I’m having trouble arguing why I should fade the Bills straight up.
PASS.
Against the spread
Buffalo is just 5-4 ATS. Vegas seems to have Indianapolis pegged; the Colts sit at 7-2 ATS.
Importantly, Indianapolis has covered 3 out of 4 times Flacco has played significantly this season, with the exception coming in last week’s loss to Minnesota.
I recommend Bills faders take this route instead of straight up.
BET COLTS +4 (-110).
Over/Under
The absences of Pittman and Coleman — potentially Cooper, too — would justifiably shy bettors away from such a strong total of 46.5. Plus, the Colts are 3-6 overall against the total, including a 4-game streak of Unders, compared to Buffalo’s 5-4 record.
However, both offenses have proven versatile enough to find help among secondary weapons. WR Josh Downs has connected well with Flacco, and the Bills can turn to TE Dalton Kincaid and RB Ray Davis to help out in the passing game to aid Allen and RB James Cook.
I would enjoy seeing the juice on the Over fall to a more favorable figure closer to kickoff, but if you have to act soon, I’m still confident in the current line. By playing indoors with his pass-run, dual-threat Game, Allen should keep the scoreboard active.
BET OVER 46.5 (-110).
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