The Baltimore Orioles (60-40) and Miami Marlins (36-65) play the 2nd game of a 3-game series Wednesday. First pitch from loanDepot park is scheduled for 6:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Orioles vs. Marlins odds and make our expert MLB picks and predictions for the best bets.

Season series: Marlins lead 1-0

The Orioles have lost back-to-back games after falling 6-3 against the Marlins Tuesday as -165 road favorites. RHP Albert Suarez allowed 6 ER in 2 innings to pick up the loss.

CF Jazz Chisholm Jr. and LF Nick Gordon each had 2 RBIs for the Marlins, who cashed as +151 home underdogs.

Orioles at Marlins projected starters

RHP Chayce McDermott vs. RHP Edward Cabrera

McDermott makes his MLB debut.

  • According to MLB Pipline, is 7th-best prospect in organization
  • 2024 stats with Triple-A Norfolk: 3-5, 3.96 ERA (91 IP, 40 ER), 1.43 WHIP, 12.8 K/9 in 20 appearances (19 starts)

Cabrera (1-3, 7.36 ERA) makes his 9th start. He has a 1.67 WHIP, 5.5 BB/9 and 11.7 K/9 through 33 innings.

  • Last start: No-decision, 4 2/3 IP, 1 ER, 5 H, 5 BB, 1 K in 6-4 home win against New York Mets Friday
  • Never faced Orioles before

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Orioles at Marlins odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:10 a.m. ET.

  • Moneyline (ML): Orioles -140 (bet $140 to win $100) | Marlins +115 (bet $100 to win $115)
  • Run line (RL)/Against the spread (ATS): Orioles -1.5 (+125) | Marlins +1.5 (-150)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

Orioles at Marlins picks and predictions

Prediction

Orioles 5, Marlins 4

Moneyline

BET ORIOLES (-140).

While the Orioles are just 3-7 in their last 10 games, they are 3-2 in their last 5. They have scored 6 or more runs in 3 of their last 5 and face Cabrera, who has struggled this season with a 7.36 ERA. While McDermott is unproven, he has an opportunity to start his MLB career off on a high note against a Marlins team that is 21-33 at home this season.

Run line/Against the spread

PASS.

The moneyline is the safest play in this matchup.

Over/Under

BET OVER 8.5 (-115).

The Orioles have hit the Over in 4 of their last 5 Games, while the Marlins have hit the Over in 3 of their last 5. Miami has hit the Over in 7 of its last 10 Games and allowed 6 or more runs in 5 of its last 10.

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