The Arizona Diamondbacks (9-10) and San Francisco Giants (8-11) open a 4-game series at Oracle Park Thursday. First pitch is scheduled for 9:45 p.m. ET (FS1). Let’s analyze FanDuel Sportsbook’s lines around the Diamondbacks vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Diamondbacks won 7-6 last season

The Diamondbacks lost to the Chicago Cubs 5-3 Wednesday, closing as -122 favorites. They lost 2 of 3 in that series yet have won 5 of their last 8. Arizona is 10-9 against the spread (ATS).

The Giants beat the Miami Marlins 3-1 on the road Wednesday, winning 2 of 3 in that series. They have traded off winning and losing in their last 8 games and are 8-11 ATS on the season.

Diamondbacks at Giants projected starters

RHP Ryne Nelson vs. RHP Logan Webb

Nelson (1-2, 5.27 ERA) makes his 4th start. He has a 1.61 WHIP, 3.3 BB/9 and 8.6 K/9 in 13 2/3 innings.

  • Last start: Win, 6 IP, 1 ER, 7 H, 1 BB, 4 K in 4-2 home victory vs. St. Louis Cardinals Saturday
  • 2023 road splits: 6-3, 3.46 ERA (88 1/3 IP, 34 ER — 12 HR), 23 BB, 65 K in 15 starts and 1 relief appearance

Webb (1-1, 3.80 ERA) makes his 5th start. He has a 1.39 WHIP, 1.9 BB/9 and 6.5 K/9 in 23 2/3 innings.

  • Last start: Win, 7 IP, 1 ER, 6 H, 1 BB, 4 K in 11-2 victory at Tampa Bay Rays Saturday
  • 2023 home splits: 7-6, 2.26 ERA (111 2/3 IP, 28 ER — 8 HR), 15 BB, 100 K in 16 starts

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Diamondbacks at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:45 a.m. ET.

  • Moneyline (ML): Diamondbacks +144 (bet $100 to win $144) | Giants -172 (bet $172 to win $100)
  • Run line (RL)/Against the spread (ATS): Diamondbacks +1.5 (-152) | Giants -1.5 (+126)
  • Over/Under (O/U): 7.5 (O: -118 | U: -104)

Diamondbacks at Giants picks and predictions

Prediction

Giants 4, Diamondbacks 3

Moneyline

PASS.

There’s not great value here either way, and the Giants (-172) have lost 2 of their last 3 at home and are 3-3 straight up at Oracle Park this season. Their value isn’t great here, and it should be avoided.

Run line/Against the spread

BET DIAMONDBACKS +1.5 (-152).

The Giants have traded off winning and losing in 8 straight games, and that has expanded through all or part of 3 series. San Fran has dropped 3 of its last 5 at home and is just 1-5 ATS at home, winning by 1 in 2 of its 3 wins.

The Diamondbacks, on the other hand, have played 6 games as on the road and lost in Atlanta by 1 in 2 of those. They are 3-3 ATS away. While Nelson hasn’t been as consistent as Webb this season, he was strong on the road last season. Expect the Diamondbacks to keep this one close.

Take DIAMONDBACKS +1.5 (-152).

Over/Under

LEAN UNDER 8 (-172).

The Diamondbacks have gone Under in 4 of their last 5 Games, and they are 0-3 O/U in Nelson’s 3 starts this season.

Arizona is 9-10 O/U on the season. The Giants have gone Under in 5 of their last 8 games. They have scored 4 or fewer in 4 straight games and have allowed 3 or fewer in 2 of their last 3.

Considering the strength of the starting pitching as well, back UNDER 8 (-172).

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