On Sunday, Sept. 22 (kicking off at 4:25 p.m. ET), the San Francisco 49ers (1-1) face the Los Angeles Rams (0-2) at SoFi Stadium and are expected to win but by less than a touchdown, 25-22 (based on our computer prediction).
49ers vs. Rams predictions
- Pick ATS: Rams (+6.5)
- Pick OU: Over (43.5)
- Prediction:
49ers 25 – Rams 22
49ers vs. Rams odds and lines
National Football League odds courtesy of BetMGM. Odds updated Sunday at 5:39 a.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread favorite: 49ers (-6.5)
- Moneyline: 49ers (-300), Rams (+240)
- Total: 43.5 points
49ers betting stats
- San Francisco has one win against the spread this season.
- One of San Francisco’s two games this season has hit the over.
Rams betting stats
- Los Angeles has not won a game against the spread this season.
- One Los Angeles game (out of two) has gone over the point total this season.
- The Rams lost the only game they’ve played as the underdog this season.
49ers vs. Rams game info
- Game day: Sunday, September 22, 2024
- Game time: 4:25 p.m. ET
- TV channel: FOX
- Location: Inglewood, California
- Stadium: SoFi Stadium
- TV channel: FOX
- Live stream: Watch Redzone & other NFL content all season long on Fubo
