The San Francisco 49ers (2-2) will meet the Arizona Cardinals (1-3) at Levi’s Stadium on Sunday, Oct. 6 at 4:05 p.m. ET, and our computer prediction is a double-digit victory by the 49ers, 31-18.

49ers vs. Cardinals predictions

  • Pick ATS: 49ers (-7)
  • Pick OU: Under (49)
  • Prediction:
    49ers 31 – Cardinals 18

49ers vs. Cardinals odds and lines

National Football League odds courtesy of BetMGM. Odds updated Sunday at 1:34 a.m. ET. For a full list of Sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.

  • Spread favorite: 49ers (-7)
  • Moneyline: 49ers (-350), Cardinals (+280)
  • Total: 49 points

49ers betting stats

  • San Francisco has posted two wins against the spread this year.
  • The 49ers are unbeaten ATS (1-0) as a 7-point favorite or greater this year.
  • This year, three of San Francisco’s four games have gone over the point total.

Cardinals betting stats

  • Arizona has posted two wins against the spread this season.
  • Arizona has seen three of its four games go over the point total.
  • The Cardinals have lost both games they’ve played as underdogs this season.

49ers vs. Cardinals game info

  • Game day: Sunday, October 6, 2024
  • Game time: 4:05 p.m. ET
  • TV channel: FOX
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium
  • TV channel: FOX
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