The San Francisco 49ers (2-2) and the Arizona Cardinals (1-3) square off on Sunday, October 6, 2024 at Levi’s Stadium in a battle of NFC West foes, and here are best bets recommendations.

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Best against the spread pick

  • Pick ATS: 49ers (-7.5)
  • San Francisco has covered the spread twice in four games this season.
  • The 49ers covered the spread in their only game when favored by 7.5 points or more.
  • Arizona has two wins versus the spread in four games this season.

Best over/under pick

  • Pick OU: Under (49.5)
  • The Cardinals have played three games this season that ended with a combined score over 49.5 points.
  • The teams combine to score 49.8 points per game, 0.3 more points than this matchup’s total.
  • Combined, these teams give up 47 points per game, 2.5 fewer points than this matchup’s total.

Best moneyline bet

  • Moneyline pick: 49ers -350
  • Based on this game’s moneyline, the 49ers have an implied win probability of 77.8%.
  • San Francisco is 2-2 in games they were listed as the moneyline favorite (winning 50% of those games).
  • The 49ers have played as a moneyline favorite of -350 or shorter in just one game this season, which they won.
  • Arizona has lost both games it has played as underdogs this season.
  • The Cardinals have not entered a game this season as a bigger underdog on the moneyline than the +280 odds on them winning this game.

How to watch 49ers vs. Cardinals

  • When: Sunday, October 6, 2024 at 4:05 p.m. ET
  • Where: Levi’s Stadium in Santa Clara, California
  • TV Info: FOX
  • Live stream: Watch on Fubo! (Regional restrictions may apply)
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