The San Diego Padres (16-18) kick off a 3-Game series against the Arizona Diamondbacks (14-18) Friday night. First pitch from Chase Field is at 9:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting of 2024; Diamondbacks won 7-6 in 2023

The Padres snapped a 5-game losing streak by winning the final 2 games of their series against the Cincinnati Reds in San Diego. They last played Wednesday, beating the Reds 6-2.

The Diamondbacks have lost their last 3 series and 5 of their last 7 games. They were shut out by the Los Angeles Dodgers 8-0 at home Wednesday.

Padres at Diamondbacks projected starters

RHP Dylan Cease vs. RHP Slade Cecconi

Cease (3-2, 2.78 ERA) makes his 7th start. He has a 0.87 WHIP, 3.5 BB/9 and 10.1 K/9 in 35 2/3 innings.

  • Last start: Loss, 6 IP, 5 ER, 6 H, 3 BB, 5 K in 5-1 home loss to Philadelphia Phillies Saturday
  • Was 3-0 with 0.94 ERA in previous 3 starts

Cecconi (1-1, 2.25 ERA) makes his 3rd start. He has a 0.50 WHIP, 1 BB and 11 K in 12 innings.

  • Last start: Loss, 6 IP, 1 ER, 3 H, 1 BB, 8 K in 3-1 road loss to Seattle Mariners Saturday
  • Has allowed 2 or fewer runs in 5 of 6 career starts

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Padres at Diamondbacks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:19 a.m. ET.

  • Moneyline (ML): Padres -110 (bet $110 to win $100) | Diamondbacks -110 (bet $110 to win $100)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+150) | Diamondbacks +1.5 (-185)
  • Over/Under (O/U): 9 (O: +100 | U: -120)

Padres at Diamondbacks picks and predictions

Prediction

Padres 7, Diamondbacks 3

Moneyline

The Diamondbacks have scored 3 or fewer runs in 5 of their last 7 Games.

They have lost the 1st game of their last 9 series and are 1-9 in series openers this season.

The Padres (-110) are 8-6 on the road.

However, while -110 odds are reasonable for betting the Padres for a straight-up win, the nice plus odds on the run line and numbers behind the Padres’ wins and Diamondbacks’ losses make that a better bet.

PASS.

Run line/Against the spread

The Padres have won by 2 or more runs in 13 of their 16 wins this season.

Twelve of the Diamondbacks’ last 13 losses have been by 2 or more runs.

Since you can feel confident in a San Diego victory straight up, you should also love the odds of it covering the run line.

BET PADRES -1.5 (+155).

Over/Under

Six of the last 7 and 8 of the last 10 games for Arizona have not reached 9 total runs. Eight of their last 10 losses have had 8 or fewer runs.

However, while 3 of the Padres’ last 4 wins have not reached 9 total runs, 11 of their 16 wins this season have.

BET OVER 9 (+100).

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