The LA Rams (0-1) are on the road for a divisional matchup in Week 2 facing the Arizona Cardinals (0-1). Kickoff from State Farm Stadium is at 4:05 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Rams vs. Cardinals odds, and make our expert NFL picks and predictions.

The Rams opened their season with a 26-20 OT loss at the Detroit Lions Sept. 8, failing to cover as 5.5-point underdogs. The Under (53.5) cashed.

The Cardinals lost 34-28 at the Buffalo Bills in Week 1, covering as 6.5-point underdogs. The Over (45) hit.

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Rams at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 2:05 p.m. ET.

  • Moneyline (ML): Rams +100 (bet $100 to win $100) | Cardinals -120 (bet $120 to win $100)
  • Against the spread (ATS): Rams +1 (-110) | Cardinals -1 (-110)
  • Over/Under (O/U): 48 (O: -110 | U: -110)

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Rams at Cardinals key injuries

Rams

  • Steve Avila (knee) out
  • TE Davis Allen (back) out
  • OL Kevin Dotson (foot) questionable
  • CB Cobie Durant (toe) questionable
  • QB Jimmy Garoppolo (suspension) out
  • TE Tyler Higbee (knee) out
  • Quentin Lake (hip) questionable
  • WR Puka Nacua (knee) out
  • OT Joe Noteboom (ankle) out

Cardinals

  • WR Zay Jones (suspension) out
  • WR Xavier Weaver (oblique) questionable

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Rams at Cardinals picks and predictions

Prediction

Cardinals 24, Rams 20

Moneyline

The Cardinals (-120) have not beaten the Rams at home in 10 years and only have 2 wins over them since 2017.

But Detroit was able to run the ball against the Rams in Week 1, and the Cardinals had a top-5 rushing offense last season, led by RB James Conner.

The Rams are down to a 3rd-string left tackle and a backup center, as Noteboom and Avila both landed on injured reserve this week along with Nacua

It is Arizona’s home opener, which should give it a little extra juice.

The Cardinals will finally get the monkey off their back, but there are better odds with the spread.

PASS.

Against the spread

The Cardinals started the season 1-0 ATS. They built a 17-3 first-half lead last week over Buffalo, which then obliterated Miami on Thursday Night Football.

The Rams defense is not at the same level as Buffalo’s right now.

BET CARDINALS -1 (-110).

Over/Under

Between Conner and Rams RB Kyren Williams, this could be a run-heavy game, slowing down the pace.

Four of the last 5 meetings have not reached 48 total points.

BET UNDER 48 (-110).

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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