The Kansas City Royals (58-49) and Chicago White Sox (27-82) play the 2nd game of a 3-game series at Guaranteed Rate Field Tuesday. First pitch is scheduled for 8:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Royals vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Royals lead 10-1

The Royals won 8-5 as -169 favorites in the Monday opener as the Over (9.5) hit. SS Bobby Witt Jr. hit a grand slam in the 8th to cap a 6-run inning for the Royals.

White Sox 1B Andrew Vaughn homered in the 7th inning, and CF Luis Robert Jr. added 3 hits and an RBI. Chicago has lost 15 straight Games, 11 of which were by 3 or more runs.

Royals at White Sox projected starters

RHP Michael Wacha vs. RHP Jonathan Cannon

Wacha (7-6, 3.65 ERA) makes his 19th start. He has a 1.22 WHIP, 2.6 BB/9 and 7.7 K/9 in 101 IP.

  • Last start: No-decision, 4 2/3 IP, 3 ER, 6 H, 1 BB, 1 K in 8-6 home loss vs. Arizona Diamondbacks Wednesday
  • 2024 road stats: 3-5, 4.09 ERA (50 2/3 IP, 23 ER), 1.18 WHIP, 7.8 K/9 in 9 starts
  • 2024 vs. White Sox: 2-1, 0.90 ERA (20 IP, 2 ER), 0.70 WHIP, 8.6 K/9 in 3 starts
  • Career vs. White Sox: 4-1, 3.30 ERA (46 1/3 IP, 17 ER), 1.01 WHIP, 9.3 K/9 in 8 starts

Cannon (1-5, 4.43 ERA) makes his 11th start and 13th appearance. The rookie has a 1.35 WHIP, 2.1 BB/9 and 6.3 K/9 in 63 IP.

  • Last start: Loss, 6 IP, 2 ER, 8 H, 2 BB, 1 K in 2-1 setback at Texas Rangers Thursday
  • 2024 home stats: 1-1, 3.24 ERA (33 1/3 IP, 12 ER), 1.14 WHIP, 6.2 K/9 in 6 appearances (4 starts)
  • Career vs. Royals: 0-1, 4.09 ERA (11 IP, 5 ER), 1.09 WHIP, 5.7 K/9 in 2 starts this year

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Royals at White Sox odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:34 a.m. ET.

  • Moneyline (ML): Royals -200 (bet $200 to win $100) | White Sox +165 (bet $100 to win $165)
  • Run line (RL)/Against the spread (ATS): Royals -1.5 (-120) | White Sox +1.5 (+100)
  • Over/Under (O/U): 9 (O: -105 | U: -115)

Royals at White Sox picks and predictions

Prediction

Royals 5, White Sox 2

Moneyline

The Royals (-200) should hand Chicago its 16th consecutive loss, but it’s hard to beat MLB long term betting into lines with this much vig.

PASS. Bet the run line and/or total instead.

Run line/Against the spread

The White Sox cannot be trusted on the run line. They have lost 11 of their last 15 games — and 3 of Cannon’s last 4 outings — by 3 or more runs. Cannon has lost 4 straight decisions and allowed 3 or more ER in 4 of his last 6 appearances.

BET ROYALS -1.5 (-120).

Over/Under

The Under has gone 9-2 in 11 meetings between these teams. Chicago has scored 2 or fewer runs in 9 of the 11 contests, averaging just 1.5 runs per game. While the Royals exploded for 8 runs in the series opener, it’s unlikely that they score 6 or more Tuesday.

BET UNDER 9 (-115).

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