The Detroit Pistons (0-4) take on the Philadelphia 76ers (1-2) Wednesday at Wells Fargo Center. Tipoff is set for 7 p.m. ET. Let’s analyze BetMGM Sportsbook’s NBA odds around the Pistons vs. 76ers odds and make our expert NBA picks and predictions for the best bets.

Season series: First meeting; 76ers won 4-0 last year

The Pistons have started the season 0-4 again, but they’ve been comPetitive in covering the last 2 against the Boston Celtics and Miami Heat. They’re going to break through at some point. G Cade Cunningham has gone Over his point total in 3 of 4, and he’s averaging 26.5 points oer Game (PPG).

The Sixers decelerated the Indiana Pacers on the road Sunday with a 118-114 victory as 8-point dogs. G Tyrese Maxey had 45 points and 5 3-pointers with C Joel Embiid (knee) and F Paul George (knee) out of the lineup. Each of them will be out again Wednesday.

Pistons at 76ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NBA odds. Lines last updated at 1:09 p.m. ET.

  • Moneyline (ML): Pistons +150 (bet $100 to win $150) | 76ers -185 (bet $450 to win $100)
  • Against the spread (ATS): Pistons +4.5 (-110) | 76ers -4.5 (-110)
  • Over/Under (O/U): 219.5 (O: -110 | U: -110)

Pistons at 76ers key injuries

Pistons

  • G Ausar Thompson (illness) out

76ers

  • C Joel Embiid (knee) out
  • F Paul George (knee) out

For most recent updates: Official NBA injury report.

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Pistons at 76ers picks and predictions

Prediction

Pistons 114, 76ers 111

Moneyline

Ring the alarms. The Pistons get their first win of the season. I would much rather take the +150 ML than the 4.5-point spread. This will be a shootout between Cunningham and Maxey. While Maxey is an insane scorer, his 3-ball isn’t there yet. He’s shooting just 23.7% from deep, and if the Pistons fortify the interior, Maxey will struggle.

Meanwhile, Cunningham has the size and athleticism alongside shooting 37% from distance, which would be a career high.

Take the PISTONS +150 in the upset.

Against the spread

As mentioned, there is no interest in the spread as we’re going to send it with the ML. Instead, I’m going with CADE CUNNINGHAM OVER 24.5 POINTS (-110). Because that will have to happen for the team to win or even contend. He had 24 and 21 in the last 2 games, but that was against Boston and Miami’s defenses. The Sixers are nowhere near the caliber of them defensively.

Over/Under

The Sixers are 3-0 O/U thus far, and that perfectly articulates their lacking defense as Embiid and PG13 have been out. The Pistons are 1-3 O/U, but they’re going to have some freedom to score in bunches.

Take the OVER 219.5 (-110).

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