The Cleveland Guardians (82-62) and Chicago White Sox (33-112) play the middle contest of a 3-game series Tuesday. First pitch from Guaranteed Rate Field is set for 7:40 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Guardians vs. White Sox odds and make our expert MLB picks and predictions for the best bets.
Season series: Guardians lead 6-5
The Guardians picked up a 5-3 win in Monday’s series opener. Cleveland fired out to a 5-0 lead after 5 innings, while Chicago posted 3 runs in the bottom of the 7th and 8th to make it interesting. However, the Guards held on for the cover on the run line (-1.5, -140).
The White Sox have been terrible all season, but especially lately. Since Aug. 23, Chicago has dropped 15 of the past 17 outings, and 13 of the losses have been by 2 or more runs.
As far as totals, Chicago has cashed low in 3 of the past 4 games, while the Under is 9-4 in the previous 13 outings. For Cleveland, the Under is 4-0-1 in the past 5 games, and 7-0-2 across the previous 9 contests.
Guardians at White Sox projected starters
RHP Ben Lively vs. RHP Jonathan Cannon
Lively (11-9, 4.07 ERA) makes his 26th start. He has a 1.25 WHIP, 2.9 BB/9 and 7.2 K/9 in 135 IP.
- Last start: Loss, 4 IP, 4 ER, 7 H (1 HR), 1 BB, 3 K in 4-1 road setback vs. Kansas City Royals last Wednesday
- 2024 road splits: 4-7, 4.19 ERA, 68 2/3 IP, 32 ER, 12 HR, 1.27 WHIP, .246 opponents’ batting average (OBA), 23 BB, 59 K in 13 starts
- Career vs. White Sox: 1-1, 4.63 ERA, 11 2/3 IP, 6 ER, 1 HR, 1.54 WHIP, 6.2 K/9 in 2 starts
Cannon (3-9, 4.53 ERA) makes his 18th start and 20th appearance. He has a 1.39 WHIP, 2.9 BB/9 and 6.2 K/9 in 101 1/3 IP.
- Last start: Win, 5 2/3 IP, 1 ER, 5 H (1 solo HR), 1 BB, 4 K in 8-1 road victory vs. Baltimore Orioles last Wednesday
- 2024 home splits: 1-4, 4.17 ERA, 54 IP, 25 ER, 8 HR, 1.31 WHIP, .242 OBA, 21 BB, 36 K in 10 appearances (8 starts)
- Has never faced Guardians
Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.
Guardians at White Sox odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:36 a.m. ET.
- Moneyline (ML): Guardians -220 (bet $220 to win $100) | White Sox +184 (bet $100 to win $184)
- Run line (RL)/Against the spread (ATS): Guardians -1.5 (-142) | White Sox +1.5 (+118)
- Over/Under (O/U): 8.5 (O: -102 | U: -120)
Guardians at White Sox picks and predictions
Prediction
Guardians 4, White Sox 3
Moneyline
The Guardians (-220) will cost you more than 2 times your potential return against the hapless White Sox (+184). It will be a close shave like Monday’s series opener. Cleveland scratched out a 5-3 win, but Chicago didn’t give up, posting 3 runs against the Guardians bullpen in the late innings to make things interesting. Expect another tight Game, as the rookie Cannon hasn’t been half bad.
PASS.
Run line/Against the spread
The WHITE SOX +1.5 (+118) are worth playing in Tuesday’s middle game at plus-money.
Chicago has Cannon on the bump, and he has been pretty consistent at times. The White Sox have won 2 of the past 5 games outright, which is pretty good for them. And, against the Guardians, the White Sox are surprisingly competitive at 5-6. Take the ChiSox to cover as underdogs on the run line.
Over/Under
UNDER 8.5 (-120) is the best play on the board
The total has gone low at a 9-4 pace in the past 13 outings for the White Sox, and the total has gone low at a 7-0-2 clip in the past 9 for the Guardians. In addition, the Under has cashed in 4 of the past 5 games in the series. Lively and Cannon are capable of keeping the scores low early on, too.
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