The Boston Red Sox (31-31) and Chicago White Sox (15-47) open up a 4-game series Thursday. First pitch from Guaranteed Rate Field is scheduled for 8:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Red Sox vs. White Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: 1st meeting; White Sox won 4-2 in 2023

The Red Sox are just 5-7 in their last 12 Games, although they were able to split a 2-Game set against the visiting Atlanta Braves recently. Boston was victorious 9-0 Wednesday afternoon as a -110 favorite. SP Nick Pivetta allowed only 1 hit in 7 innings with 9 strikeouts, while 3B Rafael Devers drove in 3 with 2 HRs and CF Jarren Duran tripled and homered.

The White Sox lost to the crosstown rival Cubs by a score of 7-6 both Tuesday and Wednesday, making it 13 straight losses for the Windy City’s AL club. The White Sox own the worst record in MLB, and manager Pedro Grifol’s time as manager may be running out according to Ken Rosenthal of The Athletic.

Red Sox at White Sox projected starters

RHP Tanner Houck vs. RHP Jake Woodford

Houck (5-5, 1.85 ERA) makes his 13th start. He has a 0.96 WHIP, 1.7 BB/9 and 8.7 K/9 in 78 innings.

  • Last start: Win, 7 IP, 1 ER, 3 H, 2 BB, 6 K in 7-3 home victory vs. Detroit Tigers Friday
  • Has allowed only 1 HR this season; HR/9 (0.12) and HR/FB % (2.0%) are lowest in MLB
  • Career vs. White Sox: 0-3, 5.93 ERA (13 2/3 IP, 9 ER), 1.68 WHIP, 5.3 K/9 in 4 games (3 starts)

Woodford (0-1, 6.23 ERA) makes his 2nd start. He has a 1.62 WHIP, 4.2 BB/9 and 8.3 K/9 in 4 1/3 innings.

  • Last start: Loss, 4 1/3 IP, 3 ER, 5 H, 2 BB, 4 K in 7-2 home setback vs. Toronto Blue Jays May 28.
  • Triple-A Charlotte stats: 1-3, 5.26 ERA (49 2/3 IP, 29 ER), 1.39 WHIP, 3.1 BB/9, 7.6 K/9 in 10 starts

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Red Sox at White Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:27 p.m. ET.

  • Moneyline (ML): Red Sox -235 (bet $235 to win $160) | White Sox +194 (bet $100 to win $194)
  • Run line (RL)/Against the spread (ATS): Red Sox -1.5 (-146) | White Sox +1.5 (+122)
  • Over/Under (O/U): 8.5 (O: -122 | U: +100)

Red Sox at White Sox picks and predictions


Red Sox 5, White Sox 3



Way too much juice to lay with Boston (-235) on its own, although you can always consider it in a parlay. I would rather take a shot on the White Sox ML Friday with SP Garrett Crochet taking the bump against a Red Sox lineup that leads MLB in K% vs. LHP.

Run line/Against the spread

BET RED SOX -1.5 (-146).

The White Sox have lost 17 of their last 18 games and closer RP Michael Kopech described their situation as “not fun.” — surprise, surprise.

Neither is the idea of backing the White Sox, even getting a run and a half. Devers enters Thursday action ranked in the top 8 in the AL in homers (13 — 8th) and OBP (.380 — 6th).

The Red Sox have a clear advantage in both the hitting and pitching departments and they should win by multiple runs. Plus, RF Tyler O’Neill just returned Wednesday from a 10-day IL stint for knee iNFLaMMAtion.


BET UNDER 8.5 (+100).

Over the last month, both teams are in the bottom 6 in terms of walk percentage (White Sox 7.0%, Red Sox 7.1%), plus Houck has issued only 4 free passes over his last 20 innings. DH Eloy Jimenez is still out for Chicago and 1B Andrew Vaughn is hitting .211, so I would not expect this White Sox lineup to do much damage.

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