The Baltimore Orioles (23-12) and Washington Nationals (18-17) wrap up a 2-Game series Wednesday at Nationals Park. First pitch is scheduled for 6:45 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Orioles vs. Nationals odds and make our expert MLB picks and predictions for the best bets.

Season series: Nationals lead 1-0

Washington’s 3-0 win Tuesday snapped a 7-game losing streak vs. Baltimore dating back to 2022.

RHP Trevor Williams delivered 5 shutout innings for Washington, which cashed as a (+191) home underdog, and 4 relievers combined for 1-hit ball to seal the win. 1B Joey Meneses, OF Eddie Rosario and 3B Trey Lipscomb all drove in runs for Washington, which has won 3 of its last 4 games.

Orioles RHP Corbin Burnes recorded a 3rd consecutive quality start, but once again was doomed by a lack of run support. Despite the loss, the Orioles enter Wednesday with the best winning percentage (.657) in the American League and Burnes remains the favorite to win the AL Cy Young (+330 at FanDuel Sportsbook).

Orioles at Nationals projected starters

RHP Kyle Bradish vs. LHP Mitchell Parker

Bradish (0-0, 1.93 ERA) makes his 2nd start. He allowed 1 earned run on 4 hits and 2 walks with 5 K’s in 4 2/3 innings in his season debut, a 7-2 home win vs. the New York Yankees Thursday.

  • 2023 stats: 12-7, 2.83 ERA (168 2/3 IP, 53 ER), 1.04 WHIP, 44 BB, 168 K in 30 starts
  • Missed beginning of the year with a UCL sprain in his pitching elbow
  • Features the 2nd-lowest ERA since July 1 of last year

Parker (2-1, 2.53 ERA) makes his 5th start. The rookie has a 1.08 WHIP, 1.7 BB/9 and 8.0 K/9 in 21 1/3 innings.

  • Last start: Loss, 5 1/3 IP, 3 ER, 6 H, 2 BB, 5 K in 6-0 defeat at Texas Rangers Thursday
  • Has yet to allow a HR in 4 career starts
  • His BB/9 is 16th-lowest out of 140 SPs with at least 20 IP

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Orioles at Nationals odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:10 a.m. ET.

  • Moneyline (ML): Orioles -176 (bet $176 to win $100) | Nationals +148 (bet $100 to win $148)
  • Run line (RL)/Against the Spread (ATS): Orioles -1.5 (-110) | Nationals +1.5 (-110)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

Orioles at Nationals picks and predictions

Prediction

Orioles 4, Nationals 2

Moneyline

PASS.

This is too much juice to lay with Baltimore (-176) on its own.

Run line/Against the spread

BACK BALTIMORE -1.5 (-110).

Parker has had a nice run as far as keeping the baseball in the park, but now he will be facing an Orioles team that has the highest home-run-to-fly-ball percentage (HR/FB%) vs. LHP (16.7%) in all of baseball.

SS Gunnar Henderson, who enters Wednesday with the 3rd-shortest odds to win AL MVP (+500 at FanDuel Sportsbook), and 1B Ryan Mountcastle, who features a top-10 HR/FB% vs. LHP (33.3%) among 175 qualified hitters, are certainly candidates to go yard.

Over/Under

BET UNDER 8.5 (-105).

Bradish is in good position for a 2nd straight quality start to begin his season as he faces a Nationals team that generates the most soft contact (20.7%) vs. RHP in the league.

Washington also has the 2nd-lowest infield hit percentage (4.6%) and 3rd-highest infield fly ball percentage (13.3%), so I would not expect much traffic on the basepaths for Bradish or an Orioles pen that features strong options like RHP Yennier Cano, LHP Danny Coulombe and RHP Jacob Webb.

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