The Arizona Diamondbacks (30-35) and San Diego Padres (34-34) wrap up a 4-Game series at Petco Park Sunday. First pitch is scheduled for 4:10 p.m. ET (ESPN+). Let’s analyze FanDuel Sportsbook’s lines around the Diamondbacks vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 4-2

The Diamondbacks won the series opener Thursday by a 4-3 score, but the Padres have been rude hosts the past 2 days. San Diego won 10-3 on Friday, and 13-1 on Saturday, easily cashing as the favorite while hitting the Over both days.

Despite the 2 blowout losses, Arizona is still a respectable 5-3 in the past 8 games, while cashing the Over at 7-2 clip in the previous 9 contests.

The 23 runs scored the past 2 days is the most scored in consecutive Games by the Padres this season. The 2 routs come after a 5-Game losing skid which saw the team average just 2.2 runs per Game (RPG), cashing the Under in each outing.

Diamondbacks at Padres projected starters

RHP Scott McGough vs. RHP Adam Mazur

McGough (1-3, 6.35 ERA) makes his 1st start and 17th appearance. He has a 1.65 WHIP, 5.3 BB/9 and 5.8 K/9 in 17 IP.

  • Last start: No-decision, 2 1/3 IP, 0 ER, 1 H, 1 BB, 2 K in 40-pitch start at Padres in an 8-1 win Aug. 19, 2023
  • 2024 road splits: 0-2, 11.12 ERA (5 2/3 IP, 7 ER), 2.29 WHIP, .381 opponents’ batting average (OBA), 2 HR, 5 BB, 2 K in 6 relief appearances

Mazur (0-0, 1.50 ERA) makes his 2nd start. He has a 1.00 WHIP, 3.0 BB/9 and 6.0 K/9 in 6 IP.

  • Last start: No-decision, 6 IP, 1 ER, 2 H, 4 BB, 2 K in 4-2 road loss vs. Los Angeles Angels Tuesday in his Major League debut

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Diamondbacks at Padres odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 2:21 a.m. ET.

  • Moneyline (ML): Diamondbacks +110 (bet $100 to win $110) | Padres $130 (bet $130 to win $100)
  • Run line (RL)/Against the spread (ATS): Diamondbacks +1.5 (-196) | Padres -1.5 (+162)
  • Over/Under (O/U): 8.5 (O: -115 | U: -105)

Diamondbacks at Padres picks and predictions


Padres 8, Diamondbacks 3


The PADRES (-130) are a good play behind the rookie Mazur, who makes his home debut at Petco Park. He had a solid outing against the Angels in his 1st taste of the majors last time out.

The Diamondbacks (+110) counter with McGough, who has been a disaster in relief. He’ll serve as the opener, turning it over to an Arizona bullpen which has also been erratic, allowing 27 HR with a 4.48 ERA, which ranks 6th-worst in the majors.

Run line/Against the spread

It’s tough to trust a rookie making just his 2nd-ever start in the majors, but the PADRES -1.5 (+162) are worth a roll of the dice for the more adventurous bettor.

San Diego will get a shot at the shaky Diamondbacks +1.5 (-196) bullpen early in the game, and we could have another rout in the series finale.


OVER 8.5 (-115) is the play, based mostly on the poor pitching of McGough, and the fact the Padres have piled up 24 runs the past 2 games, and they’ll get to face the Diamondbacks for an extended period.

The Over is 4-1 in the past 5 Games for the Diamondbacks, and 7-2 in the previous 9 outings. The Padres have hit the Over in 3 of the past 4 Games at home.

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