The San Francisco Giants (29-29) welcome the New York Yankees (40-19) to Oracle Park Saturday for the 2nd of their 3-Game series. First pitch is set for 10:05 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Yankees vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Yankees lead 1-0

The Yankees opened up the lone regular season series between these 2 teams with a 6-2 win Friday. They jumped out to a 3-1 lead after the 3rd and never looked back.

The Yankees continued their win streak, having now claimed victory in 3 straight and covering in 2 of those. They are 7-2 over their last 9 games. New York sits atop the AL East and is 33-25-1 against the spread (ATS) on the season.

The Giants, who sit 3rd in the NL West, have won 6 of their last 9 games and are 28-30 ATS on the season. San Francisco has won 6 of its last 8 home games and is coming off a series in which it won 2 of 3 against the NL East-leading Philadelphia Phillies.

Yankees at Giants projected starters

RHP Cody Poteet vs. RHP Logan Webb

Poteet (1-0, 1.50 ERA) makes his 2nd start. He has a 1.00 WHIP, 0.0 BB/9 and 6.0 K/9 through 6 IP.

  • Last start: Win, 6 IP, 1 ER, 6 H, 0 BB, 4 K in an 8-2 road win over the Cleveland Guardians April 13
  • 2022 road splits (was out all of 2023 recovering Tommy John surgery): 0-1, 3.97 ERA (11 1/3 IP, 5 ER), 6 H, 1 HR, 9 BB, 6 K in 1 start and 5 relief appearances with the Miami Marlins
  • Has yet to face the Giants

Webb (4-4, 2.74 ERA) makes his 13th start. He has a 1.26 WHIP, 2.4 BB/9 and 7.6 K/9 through 72 1/3 IP.

  • Last start: No-decision, 7 IP, 0 ER, 3 H, 1 BB, 8 K in a 4-3 road loss to the New York Mets Sunday
  • 2024 home splits: 3-1, 1.03 ERA (35 IP, 4 ER), 29 H, 0 HR, 7 BB, 23 K in 5 starts
  • Career vs. Yankees: 0-1, 6.00 ERA (6 IP, 4 ER), 1.00 WHIP, 18.0 K/9 in 1 start

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Yankees at Giants odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:40 a.m. ET.

  • Moneyline (ML): Yankees +100 (bet $100 to win $100) | Giants -118 (bet $118 to win $100)
  • Run line (RL)/Against the spread (ATS): Yankees -1.5 (+172) | Giants +1.5 (-210)
  • Over/Under (O/U): 7.5 (O: -112 | U: -108)

Yankees at Giants picks and predictions

Prediction

Giants 5, Yankees 3

Moneyline

BET GIANTS (-118).

Throughout his career, Poteet is 7-13 when making an appearance, and in his 2nd start of the season against a solid Giants offense that sits 10th in batting average. He’ll have a tough task. They have scored at least 6 runs in 6 of their last 10 games.

While the Yankees have won consistently as of late, they have scored 3 or fewer in 3 of their last 5 and will have a significant pitching disadvantage with Webb having started the season strong.

Expect San Fran to use that advantage to come out on top and back GIANTS (-118).

Run line/Against the spread

PASS.

The Giants are far too expensive as a run-line underdog here and aren’t worth any play at -210. Similarly, the Yankees, with an inexperienced and potentially risky Poteet, aren’t worth a play as a run-line favorite.

Over/Under

BET OVER 7.5 (-112).

The Yankees offense is starting to click, having scored at least 6 runs in 2 of their last 3 Games. They have gone Over in 7 of their last 12 as well.

The Giants, who are 30-26-2 O/U on the season, have topped the total in 7 of their last 10 games and have allowed at least 5 runs in 6 of those while scoring at least 6 runs in 6 of them.

Considering those trends from both sides, back OVER 7.5 (-112).

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