The Arizona Cardinals (1-1) are expected to win, but by less than a touchdown (27-22 according to our computer prediction), when they face the Detroit Lions (1-1) at State Farm Stadium on Sunday, Sept. 22 at 4:25 p.m. ET.
Lions vs. Cardinals predictions
- Pick ATS: Cardinals (+3)
- Pick OU: Under (51.5)
- Prediction:
Cardinals 27 – Lions 22
Lions vs. Cardinals odds and lines
National Football League odds courtesy of BetMGM. Odds updated Sunday at 11:38 a.m. ET. For a full list of Sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread favorite: Lions (-3)
- Moneyline: Lions (-155), Cardinals (+130)
- Total: 51.5 points
Lions betting stats
- Detroit hasn won once against the spread this year.
- As a 3-point favorite or greater, the Lions have one win ATS (1-1) this season.
- Detroit has yet to go over the total this year.
Cardinals betting stats
- Arizona owns two wins against the spread this season.
- The Cardinals are yet to lose ATS (1-0) as a 3-point underdog or greater this season.
- Arizona and its opponent have yet to finish under the total this season.
- The Cardinals lost the only game they’ve played as the underdog this season.
Lions vs. Cardinals game info
- Game day: Sunday, September 22, 2024
- Game time: 4:25 p.m. ET
- TV channel: FOX
- Location: Glendale, Arizona
- Stadium: State Farm Stadium
- TV channel: FOX
- Live stream: Watch Redzone & other NFL content all season long on Fubo
