Best bets are available for when the Detroit Lions (1-1) visit the Arizona Cardinals (1-1) at State Farm Stadium on Sunday, September 22, 2024.

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Best against the spread pick

  • Pick ATS: Cardinals (+3)
  • Detroit is 1-1-0 against the spread this season.
  • The Lions have been favored by 3 points or more two times this season and covered the spread in one of them.
  • So far in 2024 Arizona has two wins against the spread.
  • This season, the Cardinals won ATS in their only game as an underdog of 3 points or more.

Best over/under pick

  • Pick OU: Under (51.5)
  • The two teams combine to score 55.5 points per game, four more points than this matchup’s total.
  • Opponents of these two teams score 42 points per game combined, 9.5 fewer than this matchup’s over/under.

Best moneyline bet

  • Moneyline: Lions (-150), Cardinals (+125)
  • Prediction:
    Cardinals 27 – Lions 22
  • Based on this contest’s moneyline, the Lions’ implied win probability is 60.0%.
  • Detroit has been the moneyline favorite just two other times so far this season, and they split the two games.
  • The Lions have played as a moneyline favorite of -150 or shorter in just two games this season, and they split 1-1.
  • Arizona lost the only game it has played as the underdog this season.
  • The Cardinals have played as an underdog of +125 or more once this season and lost that game.

How to watch Lions vs. Cardinals

  • When: Sunday, September 22, 2024 at 4:25 p.m. ET
  • Where: State Farm Stadium in Glendale, Arizona
  • TV Info: FOX
  • Live stream: Watch on Fubo!
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