The Detroit Lions (1-1) are on the road in Week 3 to take on the Arizona Cardinals (1-1). Kickoff from State Farm Stadium is at 4:25 p.m. ET (FOX). Below, we look at Lions vs. Cardinals odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Lions, after a 26-20 season-opening win at home over the LA Rams in overtime, lost 20-16 on Sunday to the Tampa Bay Buccaneers, despite being 7.5-point underdogs with the Under (51.5) cashing in. QB Jared Goff threw 2 picks and the team went 1-for-7 in the red zone.

The Cardinals bounced back from a season-opening 34-28 road loss to the Buffalo Bills to beat the Rams 41-10 at home as 1-point favorites. The Over (46.5) cashed in. QB Kyler Murray threw 3 TD passes and finished with a perfect 158.3 passer rating.

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Lions at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list NFL odds. Lines last updated Monday at 2:34 p.m. ET.

  • Moneyline (ML): Lions -165 (bet $165 to win $100) | Cardinals +140 (bet $100 to win $140)
  • Against the spread (ATS): Lions -3 (-115) | Cardinals +3 (-105)
  • Over/Under (O/U): 51.5 (O: -110 | U: -110)

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2024 betting stats

  • ML: Lions 1-1 | Cardinals 1-1
  • ATS: Lions 1-1 | Cardinals 2-0
  • O/U: Lions 0-2 | Cardinals 2-0

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Lions vs. Cardinals head-to-head

The Cardinals and Lions have faced each other 69 times. The Lions lead all-time 35-28-6. The last time they met, it was in 2021 and the Lions won 30-12.

Lions are 4-0-1 in their last 5 meetings, not having lost since 2015.

Murray is 0-2-1 in his career against the Lions. Goff, between playing for the Lions and the Rams, is 8-1 against Arizona with 14 TDs and 3 INTs.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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