The Detroit Lions (1-1) are on the road in Week 3 taking on the Arizona Cardinals (1-1). Kickoff from State Farm Stadium is at 4:25 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Lions vs. Cardinals odds, and make our expert NFL picks and predictions.
The Lions, after a season-opening 26-20 overtime win over the LA Rams, lost 20-16 at home in Week 2 to the Tampa Bay Buccaneers, going 1-for-7 in the red zone and turning the ball over twice. They were 7.5-point favorites in the Game.
The Cardinals blew out the Rams 41-10 in Week 2 behind QB Kyler Murray’s 3 TD passes and perfect 158.3 passer rating in the Game. They were 1-point favorites in their home opener.
Play our free daily Pick’em Challenge and win! Play now!
Lions at Cardinals odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Saturday at 9:21 p.m. ET.
- Moneyline (ML): Lions -150 (bet $150 to win $100) | Cardinals +125 (bet $100 to win $125)
- Against the spread (ATS): Lions -3 (-105) | Cardinals +3 (-115)
- Over/Under (O/U): 51.5 (O: -110 | U: -110)
WIN YOUR FANTASY FOOTBALL LEAGUE!
The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Save 25% off the Internet’s best-kept secret. Subscribe now!
Lions at Cardinals key injuries
Lions
- LB Alex Anzalone (concussion) questionable
- CB Terrion Arnold (illness) questionable
- G Graham Glasgow (knee) questionable
- S Ifeatu Melifonwu (ankle) out
- CB Ennis Rakestraw (hamstring) out
- WR Isaiah Williams (abdomen) questionable
Cardinals
- T Kelvin Beachum (hamstring) questionable
- WR Greg Dortch (hamstring) questionable
- DL Dante Stills (shoulder) questionable
FOOTBALL NEVER STOPS
Live games, analysis and more 7 days a week: Get ESPN+
Lions at Cardinals picks and predictions
Prediction
Lions 30, Cardinals 24
Moneyline
The Cardinals have scored the 2nd-most points in the league so far and have been basically unstoppable offensively for 6 of the 8 quarters they have played.
Detroit is No. 2 in yards, but has struggled cashing in yards for touchdowns, averaging only 21 points per game.
But the Lions are great at defending running backs, which means Arizona’s James Conner will find it tough to keep the offense on schedule.
Detroit is susceptible to mobile QBs, and Murray has rushed for over 50 yards in both games this season so far.
Lions QB Jared Goff is 8-0 in his last 8 starts vs. the Cardinals with 14 TD passes and 3 rushing TDs. The Cardinals have not beaten Detroit since 2015.
And with Beachum perhaps missing the game, it means Lions DE Aidan Hutchinson, who had 4.5 sacks in the loss in Week 2, might line up against a 3rd-string tackle for the Cardinals.
The Cardinals had 5 sacks against the Rams last week, but the Rams played with a 3rd-string left tackle. Detroit has arguably the best tackle tandem in the league.
So the Lions probably will win this Game. And while -150 odds aren’t terrible, the spread is a better bet.
PASS.
Against the spread
The Cardinals are 2-0 ATS so far this season. The Lions just haven’t gotten fully in rhythm offensively. They move the ball but haven’t scored TDs.
The defense is Arizona’s biggest question. They should be able to hang with the Lions in terms of points, but can they bottle up both RB David Montgomery and RB Jahmyr Gibbs? They struggled against Buffalo RB James Cook in Week 1.
BET LIONS -3 (-105).
Over/Under
The Over has hit in both of the Cardinals’ games this season.
The Lions went 1-for-7 in the red zone against Tampa. They won’t fail that many times against the Cardinals.
We know the Cardinals will score points. Can they score enough? This Game should be a 1-score, high-scoring Game.
BET OVER 51.5 (-110).
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.
Access more NFL coverage:
BetFTW | TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire
