The Chicago White Sox (15-34) and Toronto Blue Jays (21-26) wrap up a 3-Game set at Rogers Centre Wednesday. First pitch is scheduled for 7:07 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Blue Jays odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1

The White Sox beat the Blue Jays 5-0 as +171 road underdogs in the 2nd game of the series Tuesday as the Under (7) hit. LHP Garrett Crochet won his 4th consecutive start for the White Sox, who snapped a 4-game skid.

The Blue Jays finished with just 2 hits and were shut out for the 3rd time this season. LHP Yusei Kikuchi lost his 3rd consecutive decision for Toronto, which failed to cash as a -187 favorite.

White Sox at Blue Jays projected starters

RHP Nick Nastrini vs. RHP Chris Bassitt

Nastrini (0-2, 7.88 ERA) makes his 3rd start. The rookie has a 2.00 WHIP, 7.9 BB/9 and 9.0 K/9 in 8 innings.

  • Last start: Loss, 3 IP, 5 ER (6 R), 6 H, 5 BB, 3 K in 8-2 defeat at Philadelphia Phillies April 21
  • 2024 stats with Triple-A Charlotte: 0-4, 6.75 ERA (29 1/3 IP, 19 ER), 1.50 WHIP in 6 starts
  • Has never faced Blue Jays before

Bassitt (3-6, 5.03 ERA) makes his 10th start. He has a 1.53 WHIP, 4.3 BB/9 and 8.4 K/9 in 48 1/3 innings.

  • Last start: Loss, 5 2/3 IP, 3 ER, 5 H, 3 BB, 5 K in 4-3 home setback vs. Tampa Bay Rays Friday
  • 2024 home stats: 2-3, 4.94 ERA (27 1/3 IP, 15 ER), 1.46 WHIP in 5 starts
  • Career vs. White Sox (regular season): 3-2, 3.89 ERA (37 IP, 16 ER), 1.22 WHIP in 7 starts, including 1-0 with a 3.65 ERA (12 1/3 IP, 5 ER) last season

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White Sox at Blue Jays odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:01 a.m. ET.

  • Moneyline (ML): White Sox +200 (bet $100 to win $200) | Blue Jays -250 (bet $250 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (+100) | Blue Jays -1.5 (-120)
  • Over/Under (O/U): 8.5 (O: +100 | U: -120)

White Sox at Blue Jays picks and predictions

Prediction

Blue Jays 4, White Sox 3

Moneyline

It’s unlikely that the Blue Jays (-250) will drop 2 of 3 against the White Sox, who have the worst record in the AL. However, risking $250 to win $100 on a team that has lost 4 of 5 seems a little expensive.

PASS. Bet the RL and/or total instead.

Run line/Against the spread

While Nastrini struggled last time out, he allowed just 2 ER in his MLB debut April 15 against the Kansas City Royals (8th-best offense in MLB with 4.78 runs per game). The Blue Jays are 29th in MLB with 3.68 runs per game, so there is a chance that Nastrini could bounce back against a bottom-tier offense.

While Toronto likely wins at home with a more experienced starting pitcher, the Blue Jays have scored just 4 or fewer runs in 6 of their last 7 games — winning by 2 or more is a tough ask. We know how bad the Blue Jays offense is, but we’re not sure yet if Nastrini is actually a bad pitcher.

BET WHITE SOX +1.5 (+100).

Over/Under

The Under has hit in 10 of Chicago’s last 13 games and 8 of Toronto’s last 10. These are the 2 worst offenses in MLB this season. Nastrini’s ERA is also inflated because he’s only faced the Phillies and Royals, who have the 2nd- and 8th-highest batting averages in MLB, respectively.

BET UNDER 8.5 (-120).

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