The Chicago White Sox (17-51) and Seattle Mariners (39-30) play the 3rd contest in a 4-game series at T-Mobile Park Wednesday. First pitch is scheduled for 9:40 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the White Sox vs. Mariners odds and make our expert MLB picks and predictions for the best bets.

Season series: Mariners lead 2-0

The White Sox have dropped 3 in a row, including the first 2 of this series. Chicago pitching has been a disaster for most of the season, and lately is no exception. The White Sox have allowed 18 runs in the past 3 outings, or 6.0 runs per Game, and they have yielded at least 4 runs in 9 of the past 11 contests.

Wednesday’s starter, RHP Jonathan Cannon, was recalled from Triple-A in early June, and he appeared in relief against the Boston Red Sox Friday, working 3 scoreless innings with 3 hits allowed to pick up the traditional save in a 7-2 win.

The Mariners are 6½ Games clear of the Texas Rangers for 1st place in the AL West, and a large part of their success is playing at home. Seattle is 23-11 at T-Mobile Park while winning 9 of the past 10 at home since May 15.

White Sox at Mariners projected starters

RHP Jonathan Cannon vs. RHP Bryce Miller

Cannon (0-1, 5.94 ERA, 1 SV) makes his 4th start and 5th appearance. He has a 1.62 WHIP, 2.2 BB/9 and 9.2 K/9 in 16 2/3 innings.

  • Last start: No-decision, 5 IP, 4 ER, 8 H (2 HR), 2 BB, 5 K in 8-7 home win in 10 innings vs. Tampa Bay Rays April 27
  • 2024 road splits: 0-1, 14.73 ERA (3 2/3 IP, 6 ER), 2.73 WHIP, .474 opponents’ batting average (OBA), 0 HR, 1 BB, 5 K in 1 start

Miller (5-5, 3.81 ERA) makes his 14th start. He has a 1.02 WHIP, 2.6 BB/9 and 8.6 K/9 in 75 2/3 innings.

  • Last start: No-decision, 5 IP, 7 ER, 6 H (1 HR), 3 BB, 1 K in 10-9 road loss vs. Kansas City Royals Friday
  • 2024 home splits: 4-2, 2.13 ERA (42 1/3 IP, 10 ER), 0.87 WHIP, .169 OBA, 3 HR, 12 BB, 51 K in 7 starts

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White Sox at Mariners odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:20 p.m. ET.

  • Moneyline (ML): White Sox +198 (bet $100 to win $198) | Mariners -240 (bet $240 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (-104) | Mariners -1.5 (-115)
  • Over/Under (O/U): 7.5 (O: +100 | U: -122)

White Sox at Mariners picks and predictions

Prediction

Mariners 6, White Sox 2

Moneyline

The Mariners (-240) will cost you more than 2 times your potential return, and while the White Sox (+198) have been awful, that’s too much risk for not nearly enough reward.

Chicago pitching has been atrocious, and it is using a guy who hasn’t started a game since late April. Miller has been very good at home, too, as has Seattle in general. However, this is too much to risk straight up.

PASS.

Run line/Against the spread

The MARINERS -1.5 (-115) are worth playing on the run line, although it’s not nearly as attractive as getting plus-money laying the run and a half.

There is risk, too, as Seattle has won 3 in a row, but 2 of those victories are in 1-run games. That includes Tuesday’s 4-3 victory over the White Sox. In fact, the M’s have been involved in 8 games decided by a single run in the past 15 outings, going 6-2 in those contests. Be careful.

Over/Under

OVER 7.5 (+100) is a solid play at even-money. Cannon makes his way back into the starting rotation after receiving more seasoning in the minors. He looked good in a low-leverage situation for the traditional save last time out against Boston, but it remains to be seen how he’ll react on the road back in the rotation against a tough team with good bats at home.

Look for the M’s to do most of the heavy lifting for the Over, especially once it gets into the ChiSox ‘pen.

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